Estrogen levels and lipid peroxidation following exercise

Recent large-scale clinical trials have confirmed that estrogens are powerful antioxidants that effectively prevent lipid peroxidation. In particular, estrogen decreases oxidative modification of low-density lipoprotein both in vitro and in vivo. Estrogen levels fluctuate during the menstrual cycle and during perimenopause, and they are permanently depressed at menopause. Thus, it is of interest to evaluate the lipid peroxidation response under conditions of low estrogen status. It is of additional interest to evaluate lipid peroxidation under such conditions in response to situations that augment free radical production, such as exercise. Aerobic exercise, and more recently anaerobic exercise regimens, are reported to variably affect free radical production and lipid peroxidation. In addition to the exercising woman's estrogen status and menstrual history, other factors to consider when evaluating an exercising woman's risk for increased lipid peroxidation include the intensity of exercise and/or the woman's fitness level as well as her current dietary antioxidant status.