| 溶血磷脂酸对血脑屏障通透性的影响 |
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| 引用本文： | 余樱,张兆辉. 溶血磷脂酸对血脑屏障通透性的影响[J]. 国际脑血管病杂志, 2006, 14(4): 286-289 |
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| 作者姓名： | 余樱 张兆辉 |
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| 作者单位： | 430060,武汉大学人民医院神经内科 |
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| 摘 要： | 溶血磷脂酸是脂质代谢中的中间代谢产物,主要由活化的血小板产生,能引起海马神经元凋亡、tau蛋白异常磷酸化以及脑内皮细胞紧密连接通透性增加,与缺血性脑血管病、Alzheimer病和血管性痴呆的病理学改变密切相关,提示在病理情况下溶血磷脂酸能引起血脑屏障开放,并通过血脑屏障进入中枢神经系统,作用于各类细胞而产生不同的病变效应。
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| 关 键 词： | 溶血磷脂酸 血脑屏障 内皮细胞 星形胶质细胞 |
| 收稿时间： | 2005-10-08 |
| 修稿时间： | 2006-01-23 |
The Effect of Lysophosphatidic Acid on the Permeability of Blood-Brain Barrier |
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| Ying Yu,Zhao-Hui Zhang. The Effect of Lysophosphatidic Acid on the Permeability of Blood-Brain Barrier[J]. International Journal of Cerebrovascular Diseases, 2006, 14(4): 286-289 |
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| Authors: | Ying Yu Zhao-Hui Zhang |
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| Affiliation: | Department of Neurology, Renmin Hospital of Wuhan University, Wuhan 430060, China |
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| Abstract: | Lysophosphatidic acid is a intermediary metabolite in lipid metabolism, mainly produced from activated platelets. It may cause the apoptosis of hippocampal neurons, abnormal phosphorylation of tau protein and increased permeability of the tight junction of endothelial cells, which is closely correlated with pathological changes of ischemic cerebrovascular diseases, Alzheimer's disease and vascular dementia. It is shown that lysophosphatidic acid may induce the opening of the blood-brain barrier under pathological conditions, and enters central nervous system through the blood-brain barrier, and causes different effects of pathological changes by acting on various cells. |
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| Keywords: | lysophosphatidic acid blood-brain barrier endothelial cell astrocyte |
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