Dengue 2 genotypes in the state of Oaxaca, Mexico |
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| Authors: | A. Cisneros Á. Díaz-Badillo G. Cruz-Martínez R. Tovar L. R. Ramírez-Palacios F. Jiménez-Rojas B. Beaty W. C. Black IV M. de Lourdes Muñoz |
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| Affiliation: | (1) Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Col San Pedro Zacatenco, México;(2) Sección de Estudios de Postrado e Investigación de la Escuela Nacional de Medicina y Homeopatía del IPN, México;(3) Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca, México;(4) Laboratorio Estatal de Salud Publica de Oaxaca, Oaxaca, Servicios de Salud de Oaxaca, Oaxaca, México;(5) Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado, U.S.A. |
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| Abstract: | Summary. To genetically characterize dengue 2 (DEN-2) viruses in Oaxaca, Mexico, the C protein, and a portion of the prM protein genes of 8 isolates from the 2001 DEN epidemic were sequenced. The sequences were compared to those of prototype DEN-2 viruses from various parts of the world. Phylogenetic analysis suggested that the 2001 isolates of DEN-2 were of the American/Asian genotype and were most similar to the Jamaica and Venezuelan isolates MARA3, LARD1996 and LARD1910. Molecular analyses confirmed the origin of the isolates. This study indicates that DEN-2 strains of American/Asian genotype probably from Southeast Asian are circulating in Oaxaca. |
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