重型病毒性肝炎382例预后影响因素分析

目的探讨重型病毒性肝炎预后影响因素。方法回顾2005年1月—2010年1月商丘市第三人民医院诊治的重型病毒性肝炎382例临床资料进行总结分析。结果本组重型病毒性肝炎382例,经积极治疗死亡236例,病死率61.78%;存活146例,生存率38.22%;〈20岁组与21~50岁组病死率比较P〉0.05无显著差异性。〈20岁组和21~50岁组与〉50岁组病死率比较比较P〈0.05有显著差异性。各临床分型病死率比较P〈0.05有显著差异性。两组生化指标检测比较P〈0.05有显著差异性。结论重型病毒性肝炎患者年龄较轻病死率较低;临床分型病死率呈现为急性重型肝炎病死率〉慢性重型肝炎病死率〉亚急性重型肝炎病死率。临床生化指标总胆红素、胆固醇、凝血酶原活动度、白蛋白、甲胎蛋白等对于判断重型肝炎预后有一定意义。

Analysis of Prognostic Factors in Severe Viral Hepatitis 382 cases

Objective To investigate the prognostic factors of severe viral hepatitis.Methods From January 2005 to January 2010 diagnosis and treatment of severe hepatitis in our hospital 382 cases clinical data were analyzed.Results Totally 382 cases of severe viral hepatitis,236 patients died after active treatment,the mortality 61.78%;146 patients survived,the survival rate 38.22%;20 age group compared with the 21~50 age group mortality P0.05 there＇s not significant difference.20 years group and 21~50 age group and 50 age group compared mortality P0.05 sthere＇s ignificant difference.Comparison of the clinical classification of mortality P0.05 there＇s significant difference.Comparison of two biochemical parameters P0.05 there＇s significant difference.Conclusion The mortality of severe viral hepatitis patients younger and mortallyt lower;clinical type of order showed mortality tality chronic severe hepatitis mortality mortality of subacute severe hepatitis.Clinical and biochemical indicators of total bilirubin,cholesterol,prothrombin activity,albumin,AFP,etc.for judging the prognosis of severe hepatitis have a certain significance.