| 颅通定对烧伤早期大鼠心室肌细胞的保护作用 |
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| 引用本文： | 刘芳,吴丹红.颅通定对烧伤早期大鼠心室肌细胞的保护作用[J].咸宁医学院学报,2000,14(3):169-171. |
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| 作者姓名： | 刘芳 吴丹红 |
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| 作者单位： | [1]湖北省武汉市第三医院烧伤科,武汉 [2]湖北医科大学附属第一医院神经内科,武汉 |
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| 摘 要： | 目的：探讨中药颅通定对烧伤早期心室肌细胞保护作用物机理。方法：应用Ｃａ＾２＋荧光控针及ＥＰＣ－９光电联合检测系统测定烧伤早期大鼠心室肌细胞胞浆Ｃａ＾２＋浓度变化及颅通定对其影响。结果：烧伤对照组心室肌细胞于伤后１小时胞浆Ｃａ＾２＋浓度明显升高，６小时达高峰，１２小时后渐恢复。正常对照组及颅通定治疗组（浓度：３００μｍｏｌ／Ｌ）心室肌细胞胞浆Ｃａ＾２＋浓度未见明显升高。结论：颅通定可显著抑制烧伤早期大鼠心室肌细胞内Ｃａ＾２＋超载。
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| 关 键 词： | 颅通定 烧伤 钙离子 心肌细胞 中医药治疗 |
| 修稿时间： | 1999-12-28 |
Protective Effect of Chinese Herbal Rotundine on Ventricular Myocytes in Rat at Early Stage of Burn |
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| LIU Fang,WU Danhong.Protective Effect of Chinese Herbal Rotundine on Ventricular Myocytes in Rat at Early Stage of Burn[J].Journal of Xianning Medical College,2000,14(3):169-171. |
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| Authors: | LIU Fang WU Danhong |
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| Abstract: | Objective To investigate the protective effect of Chinese herbal Rotundine on rat ventricular myocytes after serious burn.Method Changes of cytoplsmic Ca 2 concentration in early stage of burn and the effect of Rotundine were examined by using Ca 2 fluorescent probes and EPC 9 light electricity measuement system.Result Post burn,the cytoplasmic Ca 2 concentration in burned control group increased obviously at lst h,reched its peak at 6th h,and decreased obviously at 12th h.In normal control group and Rotundine group,this index changed only slightly post burn.Conclusion Rotundine can obviously inhibit the Ca 2 overload of rat's ventricular myocytes at the early stage of burn. |
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| Keywords: | Rotundine Burn Ca~(2 ) Cardiomyocyte |
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