阿立哌唑与利培酮治疗女性精神分裂症对照研究

目的:比较阿立哌唑与利培酮治疗女性精神分裂症的疗效及不良反应。方法:将62例女性精神分裂症患者随机分为阿立哌唑组与利培酮组,每组各31例;治疗时间均为8周;采用阴性与阳性症状量表(PANSS)评定疗效,不良反应量表(TESS)评定不良反应。结果:阿立哌唑组有效率为87.10%,利培酮组有效率为90.32%,两组疗效比较,差异无统计学意义(P>0.05);阿立哌唑组不良反应少于利培酮组。结论:阿立哌唑治疗女性精神分裂症与利培酮相当,不良反应相对轻,较少引起体重增加和内分泌紊乱。

A comparative study of aripiprazole and risperidone in the treatment of female schizophrenia

Objective To compare the efficacy and side effects of aripiprazole and risperidone in the treatment of female schizophrenics.Methods 62 patients with female schizophrenics were randomly assigned to receive either aripiprazole group（n=31） or risperidone group（n=31）.The therpeutic period was eghit weeks.Study used positive and negative symptoms scale（PANSS） were used to evaluate the efficacy and the treatment emergent symptoms scale to evaluate the safety.Results There were no significant differences between aripiprazole group and risperidone group in improved rate（87.10% and 90.32%）.Aripiprazole group side effects less than risperidone group（P〉0.05）.Conclusion Aripiprazole has similar efficacy as risperidone in treatment of female schizophrenic patients,with lighter side effects,less likely to cause weight gain and endocrine disorders.