益生菌联合柳氮磺吡啶治疗溃疡性结肠炎的临床观察

目的 评价联合应用益生菌和柳氮磺吡啶治疗溃疡性结肠炎的疗效.方法 溃疡性结肠炎62例随机分成益生菌联合柳氮磺吡啶治疗组(n=31)和柳氮磺吡啶对照组(n=31),比较两组治疗效果、治疗前以及治疗3个月后患者的临床症状评分以及结肠粘膜的炎症评分、随访6个月的复发情况和药物不良反应进行评价.结果 治疗组总有效率93.55％,显著高于对照组77.42％ (P＜ 0.05)；两组在治疗前的临床症状评分、结肠粘膜炎症的评分差异均无统计学意义(P＞0.05),治疗3个月后2组的临床症状评分、结肠粘膜炎症的评分均有明显减轻(P＜0.01),但治疗组临床症状、结肠粘膜炎症的缓解程度优于对照组(P＜0.01),且两组的不良反应轻微.结论 联合应用益生菌和柳氮磺吡啶较单独使用柳氮磺吡啶治疗溃疡性结肠炎具有更好的疗效且安全,并能降低复发率.

Curative effect of the combined treatment with probiotics and sulfasalazine for ulcerative colitis

Objective To evaluate the curative effect of the combined treatment with probiotics and sulfasalazine for ulcerative colitis.Methods 62 patients with ulcerative colitis were randomized into 2 groups: treatment group(n=31),receiving probiotics and sulfasalazine and control group(n=31),receiving sulfasalazine only;the curative effect,the reoccurrence in 6 months,the change of main symptoms before and after treatment and the drug adverse reaction evaluated.The clinical symptom score and colon mucosa inflammation score were calculated and compared between the 2 groups before treatment and 3 months after treatment.Results The total effective rate of treatment group(93.55%)was significantly higher than that of control group(77.42%)(P<0.05);the clinical symptom score and colon mucosa inflammation score demonstrated no significant difference between the two groups before the treatment(P>0.05),but showed significant improvement 3 months after treatment(P<0.01),especially more obvious in the experiment group(P<0.01).Altogether 3 patients in both groups suffered from slight decrease leucocyte but without other adverse reactions.Conclusion The combined treatment with probiotics and sulfasalazine for ulcerative colitis is of better curative effect for ulcerative colitis and it can reduce the reoccurrent.