人类白细胞抗原G与子痫前期的相关性

人类白细胞抗原G（HLA—G）为非经典的HLA—I类分子，特异性高表达于母胎界面的绒毛外滋养细胞．通过诱导免疫耐受对妊娠和胚胎起到保护作用。子痫前期是产科领域危害母婴健康的主要疾病之一．子痫前期患者血清及胎盘组织HLA—G表达下降，但具体作用机制仍不清楚。随着基础研究的深入，明确了HLA—G基因、蛋白质的结构及遗传方式，在基因多态性方面做了大量研究工作，力求从基因水平阐明其与子痫前期的关系。发现部分子痫前期患者可能存在HLA—G基因缺陷，且HLA—G多态性在子痫前期及正常妊娠者中分布也不同。

Human Leukocyte Antigen G Research Progress and the Correlation with Preeclampsia

The human leukocyte antigen G(HLA-G) is non-classical HLA-I class I molecules highly expressing in the the extravillous trophoblast cells of maternal-fetal interface,which has protective effects to pregnancy and embryo by inducing immune tolerance.Pre-eclampsia is one of the major diseases in obstetric field,the expression of HLA-G in patients with preeclampsia,but the mechanism of action still unclear.The progress of basic research,the HLA-G gene and protein structures were defined,a lot of work have been ...