新诊断2型糖尿病患者内脂素、vaspin与颈动脉粥样硬化的相关性

目的 探讨初发2型糖尿病（T2DM）患者血清内脂素（visfatin）、vaspin水平与颈动脉粥样硬化（AS）的关系.方法 将100例初发2型糖尿病患者根据颈动脉内膜中层厚度（CIMT）分为非AS组,早期AS组和严重AS组,并配对选取33例无糖尿病的健康者为对照组.采用酶联免疫吸附试验（ELISA）测定血清visfatin、vaspin水平.结果 （1）糖尿病早期AS组和严重AS组的visfatin水平明显高于对照组和糖尿病非AS组（P＜0.01）；糖尿病非AS组和早期AS组的vaspin水平均高于对照组（P＜0.01）,严重AS组的vaspin水平明显低于糖尿病早期AS组（P＜0.05）.（2）偏相关分析显示visfatin与腰臀比（WHR）、三酰甘油（TG）、CIMT呈正相关（P＜0.05）,vaspin水平与HOMA-IR呈正相关（P＜0.05）,visfatin与vaspin无统计学关联（P＞0.05）.（3）Logistic回归分析结果显示,患者年龄、收缩压（SBP）、低密度脂蛋白胆固醇（LDL-C）、visfatin为CIMT的独立危险因素（P＜0.05）.结论 初发2型糖尿病患者血清visfatin和vaspin水平与肥胖、胰岛素抵抗密切相关；血清visfatin水平升高可能与颈AS形成密切相关.

Association of serum visfatin and vaspin with carotid atherosclerosis in newly type 2 diabetic patients

Objective To investigate the serum visfatin and vaspin with carotid atherosclerosis in newly type 2 diabetic patients（T2DM）.Methods 100 T2DM patients were divided into three subgroups serum visfatin and vaspin were measured by ELISA.Results （1） The fasting serum visfatin levels were significantly higher in the diabetic patients with atherosclerosis groups than the healthy subjects and the diabetic patients without atherosclerosis （P ＜ 0.01）.The fasting serum vaspin levels were significantly higher in early atherosclerosis group and without atherosclerosis than subjects （P ＜ 0.01）.The fasting serum vaspin levels were significantly lower in the serious atherosclerosis group than early subjects （P ＜ 0.05）.（2）Partial correlations demonstrated that the visfatin level was positively correlated with WHR,TG,CIMT（P ＜ 0.05）,and the vaspin level was positively correlated with HOMA-IR（P ＜ 0.05）.Serum visfatin was non-correlation（P ＞ 0.05）.（3）Logistic regression analysis showed that visfatin was the independent factors influencing the atherosclerosis.Conclusion Serum visfatin and vaspin are correlated with fatty and insulin resistance;hign serum vaspin is correlated with atherosclerosis in newly T2DM.