| 姜黄素抗肝纤维化的实验研究 |
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| 引用本文： | 纪辉,迟宝荣,任立群,张一宁,李相军,石艳. 姜黄素抗肝纤维化的实验研究[J]. 辽宁中医杂志, 2009, 0(8) |
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| 作者姓名： | 纪辉 迟宝荣 任立群 张一宁 李相军 石艳 |
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| 作者单位： | 吉林大学第一医院消化内科;吉林大学药学院实验药理与毒理实验室;吉林大学第一医院儿内一科; |
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| 基金项目： | 吉林省科技厅基金资助项目(20030436) |
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| 摘 要： | 目的:探讨姜黄素的抗肝纤维化作用。方法:将大鼠随机分为正常对照组、模型组、高、中、低3个剂量姜黄素组和阳性对照组,用皮下注射CC l4法诱导大鼠肝纤维化。测量并计算肝脏指数;测定各组大鼠ALT及AST活性以评价肝功能;同时观察各组大鼠肝脏形态学变化。结果:模型组大鼠肝脏指数均明显低于正常对照组(P<0.01),姜黄素治疗组大鼠肝脏指数明显高于模型组大鼠(P<0.05)。与正常组大鼠比较,模型组大鼠肝脏AST和ALT均显著升高(P<0.01),给予姜黄素治疗后,各治疗组大鼠肝脏AST和ALT活性均显著下降(P<0.05)。HE染色及M asson三色染色显示,秋水仙碱治疗组及各剂量姜黄素治疗组可见肝损伤病变明显减轻,纤维组织增生程度也明显轻于模型组。结论:姜黄素能明显减轻CC l4所致肝损伤,保护肝脏正常结构和功能,延缓肝纤维化。
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| 关 键 词： | 姜黄素 肝纤维化 胶原 |
Prophylactic Effects of Curcumin on Rats Hepatic Fibrosis |
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| JI Hui,CHI Bao-rong,REN Li-qun,ZHANG Yi-ning,LI Xiang-jun,SHI Yan. Prophylactic Effects of Curcumin on Rats Hepatic Fibrosis[J]. Liaoning Journal of Traditional Chinese Medicine, 2009, 0(8) |
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| Authors: | JI Hui CHI Bao-rong REN Li-qun ZHANG Yi-ning LI Xiang-jun SHI Yan |
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| Affiliation: | 1.Department of Gastroenterology;First Affiliated Hospital of Jilin University;Changchun 130021;Jilin;China;2.School of Pharmacy;Jilin University;3.Paediatrics;China |
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| Abstract: | Objective:To detect the prophylactic effects of curcumin on rats hepatic fibrosis.Methods:The rats were divided into 6 group,normal control group,model group,positive control group,high-dose,middle-dose and low-dose curcumin group,except normal group,all other group were given CCl4 to induce liver fibrosis.When the research was over,the index of liver was detected.The activity of AST and ALT in all 6 group were detected.Morphology changes were observe by HE and Masson stain.Results:The liver index of model ... |
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| Keywords: | Curcumin liver fibrosis collagen |
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