| 冬虫夏草醇提取物对大鼠缺血再灌注过程心肌保护作用研究 |
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| 引用本文： | 刘凤芝,李延平,黄明莉,姜杰玲,谢振华,赵雅君,孙金圣,王孝铭. 冬虫夏草醇提取物对大鼠缺血再灌注过程心肌保护作用研究[J]. 中国病理生理杂志, 1999, 15(3): 240-241 |
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| 作者姓名： | 刘凤芝 李延平 黄明莉 姜杰玲 谢振华 赵雅君 孙金圣 王孝铭 |
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| 作者单位： | 哈尔滨医科大学病理生理教研室,哈尔滨,150086 |
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| 摘 要： | 目的和方法：观察冬虫夏草对缺血再灌注过程心肌保护作用。采用Ｌａｎｇｅｎｄｏｒｆ非循环式离体心脏灌流方法,与正常对照组、缺血再灌组、刺五加注射液用药组相对比,研究了冬虫夏草醇提取物对大鼠心肌缺血－再灌注过程脂质过氧化产物（ＭＤＡ）和腺嘌呤核苷酸含量的影响。结果：冬虫夏草醇提取物显著降低了再灌注心肌的ＭＤＡ水平（Ｐ＜０．０１）及显著提高了心肌中腺嘌呤核苷酸含量（Ｐ＜００１）。结论：冬虫夏草可通过改善心肌的能量代谢减少缺血再灌注损伤,对心肌的保护作用明显优于刺五加注射液
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| 关 键 词： | 腺嘌呤核苷酸类 心肌再灌注损伤 中草药 |
The protective effect of Cordyceps Sinensis (Berk) succi on the myocardium during ischemia reperfusion |
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| LIU Feng-Zhi,LI Yan-Ping,HUANG Ming-Li,JINANG Jie-Ling,XIE Zhen-Huan,ZHAO Ya-Jun,SUN Jin-Sheng,WANG Xiao-Ming. The protective effect of Cordyceps Sinensis (Berk) succi on the myocardium during ischemia reperfusion[J]. Chinese Journal of Pathophysiology, 1999, 15(3): 240-241 |
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| Authors: | LIU Feng-Zhi LI Yan-Ping HUANG Ming-Li JINANG Jie-Ling XIE Zhen-Huan ZHAO Ya-Jun SUN Jin-Sheng WANG Xiao-Ming |
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| Abstract: | AIM and METHODS:We adapted the none circulating method perfused rat heart and high performance liquid chromatography technique (HPLC) and compared with the control group, the ischemia reperfusion group and the Acanthopanox Senticosus group, studied the effect of Cordyceps Sinensis (Berk) succi on the content of adenine nucleotides and MDA during ischemia reperfusion. RESULTS:It was shown that adenine nucleotide and total adenine nucleotide pool level increased obviously in the Cordyceps group and the level of MDA in the cardium decreased obviously during ischemia reperfusion ( P <0.01). CONCLUSION:Cordyceps can reduce ischemial reperfusion injury by improving cardial energy metabolism and the protective effect of Cordyceps in much better than that of the Acanthopanax Senfi Cosus. |
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| Keywords: | Adenine nucleotides Myocardial reperfusion injury Drugs Chinese herbal |
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