The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis |
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| Authors: | Vita M Golubovskaya Min Zheng Li Zhang Jian-Liang Li William G Cance |
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| Affiliation: | (1) Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA;(2) UF Shands Cancer Center, Gainesville, FL, USA;(3) Interdisciplinary Center for Biotechnology Research, Gainesville, FL, USA |
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| Abstract: | Background Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in survival signaling. FAK has been shown to be overexpressed in breast cancer tumors at early stages of tumorigenesis. |
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