FeNO在不同妊娠周期孕妇及妊娠哮喘患者中的变化及意义

目的：观察呼出气一氧化氮（FeNO）在不同妊娠周期孕妇及妊娠哮喘患者中的变化，并探讨其在妊娠期哮喘患者中的诊治意义。方法收集健康妊娠女性46例（HP组），健康非妊娠女性30例（HNP组），哮喘非妊娠女性30例（ANP组），哮喘妊娠期女性26例（AP组）。比较各组及HP组中不同妊娠周期孕妇的FeNO水平；分析AP组患者FeNO水平与第1秒用力呼气量占预计值的百分比（FEV1%）、最大呼气流速峰值占预计值百分比（PEF%）的相关性。结果 AP组及ANP组FEV1%、PEF%均明显低于HNP组及HP组，FeNO水平均明显高于HNP组及HP组，差异均有统计学意义（均P＜0.05）；HNP组与HP组、AP组与ANP组FeNO水平、FEV1%及PEF%的差异均无统计学意义（均P＞0.05）。不同妊娠周期孕妇FeNO水平的差异均无统计学意义（均P＞0.05）。AP组患者FeNO水平与FEV1%及PEF%均无明显相关性（r=0.250、0.272，P＞0.05）。结论妊娠及妊娠周期对FeNO水平无明显影响， AP患者FeNO水平明显升高，FeNO水平与肺功能无明显相关。

Variability of fractional nitric oxide in women of different gestation periods and in asthmatic pregnant women

Objective To assess the changes of fractional concentration of exhaled NO （FeNO） in women of different gestation periods and in asthmatic pregnant women. Methods Forty six healthy pregnant women（HP group） and 30 nonpreg-nant healthy women （HNP group）, and 30 non- pregnant asthmatic women （ANP group） and 26 pregnant asthmatic women （AP group） were enrolled in the study. The FeNO levels in 4 groups and in different gestation periods of HP group were evaluated. The correlations of FeNO level with forced expiratory volume in the first second （FEV1）/predicted FEV1 （FEV1%） and peak expiratory flow （PEF）/predicted PEF （PEF%） values in AP group were analyzed. Results The values of FEV1%and PEF%were significant-ly decreased and the FeNO levels were elevated in AP and ANP groups as compared to HNP and HP groups （P〈0.05）. No sig-nificant differences of FeNO levels and FEV1%and PEF%values between HNP and HP groups or between ANP and AP groups were found （P〉0.05）. There were no significant differences in FeNO levels among different gestation periods in HP group （P〉0.05） and no significant correlations of FeNO levels with FEV1%and FeNO values in AP group were revealed （r=0.250, 0.272, re-spectively, P〉0.05）. Conclusion FeNO level may not be influenced by pregnancy status and different gestation period; the FeNO level is increased in asthmatic pregnant women, however, it may not be correlated with the pulmonary function.