KLF8蛋白膀胱癌组织中的表达及与预后的关系

目的：探讨KLF8蛋白在膀胱癌中的表达，并分析其与临床病理特征及预后的关系。方法选择膀胱癌标本137例，正常膀胱组织标本19例，采用免疫组织化学方法，检测膀胱癌和正常组织中KLF8蛋白的表达，并结合临床资料进行分析。结果正常组织中KLF8蛋白的表达水平明显低于肿瘤组织（P＜0.001）。低级别和高级别膀胱癌中KLF8蛋白表达的阳性率分别为37.2%、58.5%，差异有统计学意义（P＜0.05）。非肌层浸润性膀胱癌和肌层浸润性膀胱癌中KLF8蛋白表达的阳性率44%和67.4%，差异有统计学意义（P＜0.05）。本组随访7-112个月，在肌层浸润性膀胱癌中，Kaplan- Meier生存显示：KLF8蛋白的阳性表达与膀胱癌患者的总生存率有关（P＜0.05）。结论 KLF8蛋白的表达在膀胱癌组织中明显高于正常组织，KLF8蛋白的表达与膀胱癌的分级、分期、预后有关；与患者的年龄、性别、肿瘤的数目无相关性（P＞0.05）。KLF8蛋白的检测有助于膀胱癌的诊断及预后的评估。

Expression of KLF8 protein in bladder cancer and its relation to prognosis

Objective To investigate the expression of KLF8 in bladder cancer and its relation to the prognosis of patients. Methods The expression of KLF8 in 137 urothelial bladder cancer and 19 normal bladder tissue samples was detected by im-munohistochemistry, and its relation to clinicopathological features was analyzed. Results The positive rate of KLF8 protein was significantly higher in bladder cancer than that in normal bladder tissue （P〈0.001）. The positive rate of KLF8 protein was 37.2%in low grade bladder cancer and 58.5%in high grade bladder cancer （P〈0.05）. It was significantly lower in non- muscle- invasive bladder cancer than that in muscle invasive bladder cancer （44%, 67.4%, P〈0.05 ）. The patient was followed up for 7-112 months, Kaplan- Meier analysis showed that positive expression of KLF8 was significantly associated with overal survival of pa-tients with muscle- invasive- bladder cancer （P〈0.05）. Conclusion The expression of KLF8 protein is high in bladder cancer, which is correlated with classification, TMN stage and prognosis of the disease.