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| 红芪多糖对改善2型糖尿病模型大鼠胰岛素抵抗的影响 | |
| 引用本文： | 金智生,李娟娥,张东鹏,周强. 红芪多糖对改善2型糖尿病模型大鼠胰岛素抵抗的影响[J]. 中国中医药信息杂志, 2007, 14(5): 27-28 |
| 作者姓名： | 金智生 李娟娥 张东鹏 周强 |
| 作者单位： | 甘肃中医学院,甘肃,兰州,730000 |
| 摘 要： | 目的观察红芪多糖(HPS)对2型糖尿病(T2DM)大鼠胰岛素抵抗的治疗作用。方法采用高热量饲料加低剂量注射链脲佐菌素(STZ)造模,分别予二甲双胍及HPS进行干预,测定干预后血糖(FPG)、血清胰岛素(Ins)、C肽(CP)、游离脂肪酸(FFA)水平,计算胰岛素敏感指数(ISI)。结果HPS可降低高热量饲料加STZ所致T2DM大鼠FPG,增加ISI,降低Ins及CP分泌,抑制FFA的产生。结论HPS可通过多途径多环节减轻糖尿病模型大鼠的胰岛素抵抗。 |
| 关 键 词： | 红芪多糖 糖尿病模型大鼠 胰岛素抵抗 |
| 文章编号： | 1005-5304（2007）05-0027-02 |
| 收稿时间： | 2006-07-12 |
| 修稿时间： | 2006-07-12 |
Effect of Hedysarum Polybotys Saccharide on Insulin Resisance of Experimental NIDDM Rats |
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| JIN Zhi-sheng, LI Juan-e, ZHANG Dong-peng, et al. Effect of Hedysarum Polybotys Saccharide on Insulin Resisance of Experimental NIDDM Rats[J]. Chinese Journal of Information on Traditional Chinese Medicine, 2007, 14(5): 27-28 | |
| Authors: | JIN Zhi-sheng LI Juan-e ZHANG Dong-peng et al |
| Affiliation: | Gansu College of TCM, Lanzhou 730000, China |
| Abstract: | Objective To investigate the effect of Hedysarum Polybotys saccharide(HPS)on insulin resistance rats.Methods The model of type 2 diabetic-insulin resistance rat was successfully made by STZ and high caloric diet.Then the rats were intervene by Metformin(MT)and HPS.Results Compared with the model group,the level of blood glucose,INS and CP were lowered,ISI were improved and FFA were restrained by HPS.Conc(?)sion HPS can reduce the insulin resistance in multiple ways. |
| Keywords: | Type 2 diabetes mellitus Hedysarum Polybotys saccharide insulin resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |