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Cylindrical spirals of myofilamentous origin associated with exertional cramps and rhabdomyolysis |
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| Authors: | Gil I Wolfe Dennis K Burns Daniel Krampitz Richard J Barohn |
| Affiliation: | a Department of Neurology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-8897, USA b Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA |
| Abstract: | We describe the presence of cylindrical spirals on muscle biopsy from a 31-year-old man who developed rhabodomyolysis following a long run. He had a prior history of exertional cramps and myoglobinuria. His maternal grandfather had similar symptoms. Transmission electron micrographs demonstrated continuity between the lamellae of the cylindrical spirals and native myofilaments. Whether these unusual structures confer a derangement in myofilament function is uncertain. |
| Keywords: | Cylindrical spirals Myofilament Cramps |
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