Toll样受体与子宫内膜及子宫内膜异位症

子宫内膜异位症（EMs）发病机制尚未完全阐明。大量研究表明,免疫因素在EMs的发病机制中起重要作用。EMs免疫应答异常主要是巨噬细胞数量和活性增加及其分泌产物,如生长因子、细胞因子和血管生成因子的改变。Toll样受体（TLRs）识别特异性的病原体相关分子模式,启动和介导免疫应答,在固有免疫中发挥重要作用,并诱导产生适应性免疫反应。TLRs在正常子宫内膜中的生理作用以及在EMs中的相关研究已逐步开展,对其深入认识和研究将为EMs诊断、治疗和预后判断提供新思路和手段。

Toll-like Receptors and Endometrium and Endometriosis

Endometriosis′s pathogenesis remains elusive. A number of papers have already demonstrated that the occurrence of endometriosis is closely related to the aberrant of the immunologic response system of organism. The deregulation of immune response in endometriosis is characterised by increased number of activated macrophages and their secreted products, such as growth factors, cytokines, and angiogenic factors. Toll-like receptors（TLRs）recognize specific pathogen associated molecular patterns and serve an essential role in the innate immune system by initiating and directing immune response to microbial pathogens. Recent studies have shown the physiological role of TLRs in the normal endometrium and the relationship between TLRs and endometriosis. Further studies may provide more insight into the diagnosis, treatment and prognostic indicator of endometriosis.