甲胎蛋白与癌胚抗原联合检测在肝癌鉴别诊断中应用价值

目的探讨联合检测甲胎蛋白(AFP)与癌胚抗原(CEA)在原发性肝癌和转移性肝癌诊断中的应用价值。方法选择经临床病理学检查确诊的肝癌患者98例,根据疾病诊断分为原发性肝癌组(56例)和转移性肝癌组(42例),同期健康体检者作为对照组(30例)。采用电化学发光法测定血清AFP和CEA浓度,并对3组结果进行分析。结果原发性肝癌组血清AFP和CEA含量均明显高于对照组(P均0.05),原发性肝癌组血清AFP含量明显高于转移性肝癌组,差异有统计学意义(P=0.012);转移性肝癌组中CEA含量均明显高于原发性肝癌组和健康对照组,差异有显著统计学意义(P均0.01)。结论联合检测血清AFP和CEA的含量能更好地诊断和鉴别诊断原发性肝癌与转移性肝癌,对鉴别肝癌的类型具有一定的指导意义。

Application of combined detection of alpha-fetoprotein and carcinoembryonic antigen in differential diagnosis of hepatic carcinoma

Objective To investigate the application value of combined detection of AFP and CEA in the diagnosis of primary hepatic carcinoma and metastatic hepatic carcinoma. Methods Total of 98 patients with pathologically diagnosed liver cancer were divided into primary liver cancer group （56 cases）, metastatic liver cancer group （42 cases） and the healthy physical examination for the same period were taken as control group （30 cases）. The electrochemical luminescence method was applied to detect serum AFP and CEA concentration, and analyzed the results were analyzed. Results Serum AFP and CEA concentration of primary liver cancer group and metastatic liver cancer group were significantly higher than those of control group （all P ＜ 0.05）, serum AFP of primary liver cancer group was significantly higher than that of metastatic liver cancer group （P = 0.012）, and CEA concentration of metastatic liver cancer group was significantly higher than primary liver cancer group and control group （both P ＜ 0.01）. Conclusions Combined detection of AFP and CEA can differentially diagnose primary hepatic carcinoma and metastatic hepatic carcinoma, which has a certain significance to identify the type of hepatic carcinoma.