多靶点治疗狼疮性肾炎的临床研究

【目的】评估霉酚酸酯（MMF）、环磷酰胺（CTX）联合激素多靶点治疗狼疮性肾炎（LN）的疗效和安全性。【方法】将36倒活动性LN随机分成两组进行治疗,分别为三联治疗组（A组,n=18）和常规治疗组（B组,n=18）,并观察比较病人血清抗双链DNA、ANA、补体C3和24h尿蛋白定量等实验室指标变化及疗效和不良反应。【结果】A组总有效率优于B组,两组比较差异有显著性（P〈0．05）,A组的实验室指标较B组明显改善,两组间的不良反应发生率无明显差异。【结论】多靶点治疗是治疗活动性LN的一种安全、有效的方法。

Clinical Study of Multi-target Therapy of Lupus Nephritis

[Objective]To investigate the efficacy and adverse reaction of mycopbenolate mofetil（MMF）, a new type of immunodepressant, combined with cytoxan（CTX） and glucoeorticoid for the treatment of lupus nephritis （LN）. [Methods] Thirty six patients of active lupus nephritus（ALN） were randomly divided into two groups. Group A（ n =18） were treated by multi-target therapy. Group B（ n = 18） were treated with standard eorticosterone combined CTX therapy. Changes of laboratory indices including serum levels of anti-double strain DNA antibody（AdsDNA）, ANA, C3, and protein quantitation in 24-hour urine as well as the therapeutic efficacy and side reaction in both groups were observed and compared. [Results]The effective rate of multi- target therapy group was better than that of standard group, and there was significant difference between two groups （ P 〈0.05）. The laboratory indices in Group A were much more evidently ameliorated than Group B. The side reactions of both groups revealed no obvious difference. [Conclusion] Multi-target therapy is a safe and effective method for the treatment of ALN.