帕利哌酮缓释片治疗老年精神分裂症患者的疗效和安全性研究

目的比较帕利哌酮缓释片与奋乃静片治疗老年期精神分裂症的疗效和安全性。方法将63例老年期精神分裂症患者随机分为两组，分别予帕利哌酮缓释片和奋乃静片治疗8周，治疗前后采用阳性与阴性症状量表（PANSS）评定疗效、个人和社会功能量表（PSP）评定社会功能改善情况和副反应量表（TESS）观察不良反应。结果观察组和对照组总有效率分别为84．38％和80．65％，差异无统计学意义（P〉0．05）。观察组不良反应低于对照组。结论帕利哌酮缓释片治疗老年精神分裂症疗效较好，安全性高，有利于长期巩固维持治疗。

Study on efficacy and safety of paliperidone in the treatment of elderly patients with schizophrenia

Objective To investigate the efficacy and safety of paliperidone and perphenazine tablets in the treatment of eldedy schizophrenia. Methods A total of 63 elderly schizophrenia randomlized into two groups were respectively given Paliperidone or perphenazine for 8 weeks. Clinical effect was evaluated was Positive and Negative Symptom Scale （ PANSS ） , Personal and Social Performance Scale （ PSP ） and the assessment of adverse drug reaction was evaluated with Traumatic Exposure Severity Scale （ TESS ） . Results The total effective rate was respectively 84.38% or 80.65%. There were no significant differences in the clinical effect between the two groups. And side effects of Paliperidone were less than perphenazine. Conclusion Paliperidone has good efficacy and high safety in the treatment of elderly schizophrenia patients. So it is beneficial to maintained treatment.