AIDS抗病毒治疗死亡病例临床分析

目的了解AIDS抗病毒治疗死亡病例特点,为开展AIDS抗病毒治疗提供有价值的参考信息。方法对2005—2012年在我院门诊抗病毒治疗过程中死亡患者的病历进行回顾性分析,总结其临床特点。结果在我院治疗过程中患者累计死亡102例,年龄(46.13±15.24)岁,男性占77.45%,女性占22.55%,病死率为3.20%。死亡患者的基线CD4+T淋巴细胞计数为(72.61±77.15)个/mm3,CD4+T淋巴细胞计数<100个/mm3者占72.55%,治疗12个月内死亡者占71.57%,CD4+T淋巴细胞计数>50个/mm3的患者死亡年龄大于CD4+T淋巴细胞计数≤50个/mm3的患者(P<0.05)。结论 AIDS相关疾病是患者死亡的主要原因,死亡多发生于CD4+T淋巴细胞计数<100个/mm3和治疗后的1年内。

Clinical characteristics of AIDS deaths after antiviral treatment

Objective To investigate the clinical characteristics of AIDS deaths receiving highly active antiretroviral therapy （HAART）, so as to provide reference for HAART in AIDS patients. Methods The data of dead patients receiving HAART in our hospital from 2005 to 2012 were analyzed retrospectively to summarize the clinical characteristics. Results A total of 102 patients treated in our hospital were dead during HAART with the average age of 46.13±15.24 years, of whom 77.45% were males, and 22.55% females. The mortality rate was 3.20%. The baseline CD4^＋ T lymphocyte count of the deaths was 72.61 ±77.15 /mm^3, and the patients with baseline CD4^＋ T lymphocyte count 〈100/mm^3 accounted for 72.55%. The patients who were dead during 12 months of treatment accounted for 71..57%. The age of death in patients with CD4^＋ T lymphocyte count 〉50/mm^3 was significantly older than that in patients with CD4^＋ T lymphocyte count ≤50/mm^3. Conclusions AIDS-related diseases are the main causes of death. Patients with CD4^＋ T lymphocyte count 〈100/mm^3 and receiving HAART for no more than 1 year have a high mortality rate.