卫辉市部分乙肝感染者家庭的感染模式分析

目的]通过乙肝病毒在家庭中的感染模式的研究，了解其家庭聚集性分布特点，为制定防治策略提供依据。方法]2002年9月和2004年4月，选择卫辉市乙肝感染者的家庭成员作为研究对象，采用酶联免疫吸附试验（ELISA）测其HBV感染的血清学指标，进行感染模式的分析。结果]本次调查共检查来自233个家庭的748人，被调查家庭成员2～6人，年龄2～86岁，男性461人，女性287人。检出HBV感染血清标本474份，HBV感染检出率为63．39％（474／748）。本次调查共发现了22种HBV感染模式，呈现更多样化。家庭中感染者最少1人，有3户，仅占总户数的1．29％。有2人及以上者230户，占总户数的98．71％，最多5人。在HBV感染者中，抗-HBs出现率女高于男，提示HBV感染后，女性更易进入恢复期。HBeAg检出峰值区位于5～14岁，少年儿童在家庭中成为家庭水平传播的主要传染源。夫妻间HBV传播率虽高，但转慢率不高，多数自然痊愈。结论]卫辉市的HBV感染呈现明显的家庭聚集现象，阳断HBV在家庭内传播为控制HBV感染的主要措施。

Analyse Infection Module in Families by Carrying HBV

Objective]Study on infection module of HBV in family,know about it's distribution earmark in homely conglomeration,providing attestation in prevention and treatment strategy.Methods]Select family members by carrying HBV as studying aim from Weihui city,on September,2002 and on April,2004.Examine their HBV symbol of serum with ELISA,then analyse their infection module.Results]In this observation,748 members in 233 families are eamined.At least 2 persons and at most 6 persons per family,and the junior is 2 ages,the older is 86 ages.748 persons contain 461 males and 287 females.474 serum specimen examined are infected by HBV.Positive rate is 63.39%.22 HBV infection modules are founded in this observation.Showing the more variety.In these families,only one infected person is 3,holding 1.29%,and the other is 230,holding 98.71%,the most infected members are five.In these infected persons,in anti-HBs bring rate,the females are higher than the males,reveal that the females easily recover from HBV infection.The highest amount of HBeAg is in children of five to fourteen years old,reveal that the children are the major source of infection in these families.Although the HBV spreading rate is higher between husband and wife,but their chronic carriers are lower,majority are recoverable.Conclusion]The HBV infection shows evidently in homely conglomeration in Weihui city,so the major controllable way against HBV infection is stopping HBV spreading from family.