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| 基于整合药理学研究参麦注射液治疗心力衰竭的生物作用机制 | |
| 引用本文： | 吉米丽汗·司马依,买买提明·努尔买买提,艾尼瓦尔·吾买尔,努丽比亚·买合木提,买尔旦·玉苏甫,木哈待斯·努尔,周文婷. 基于整合药理学研究参麦注射液治疗心力衰竭的生物作用机制[J]. 中国临床药理学杂志, 2021, 0(1): 75-77 |
| 作者姓名： | 吉米丽汗·司马依 买买提明·努尔买买提 艾尼瓦尔·吾买尔 努丽比亚·买合木提 买尔旦·玉苏甫 木哈待斯·努尔 周文婷 |
| 作者单位： | 新疆医科大学药学院;新疆医科大学维吾尔医学院 |
| 基金项目： | 国家自然科学基金资助项目(81660696);新疆维吾尔自治区自然科学基金资助项目(2019D01C217);新疆自治区“十三五”重点学科建设基金资助项目(2016);新疆医科大学博士后科研启动基金资助项目(170401)。 |
| 摘 要： | 本文利用中医药整合药理学研究平台(TCMIP V2.0)视角,探索参麦注射液治疗心衰的作用机制,借助于本平台的分析功能,构建参麦注射液治疗心衰的"中药-化学成分-核心靶标-关键通路"多维网络,从不同的角度探索参麦注射液干预心衰的潜在分子机制.在TCMIP V2.0分析参麦注射液治疗心衰的分子机制研究结果表明,参麦注射液... |
| 关 键 词： | 整合药理学 参麦注射液 心力衰竭 分子机制 |
Study on the biological mechanism of the action of Shenmai injection treatment of chronic heart failure by using integrative pharmacology |
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| JIMILIHAN Si-ma-yi,MAIMAITIMING Nu-er-mai-mai-ti,AINIWAER Wu-mai-er,NULIBIYA Mai-he-mu-ti,MAIERDAN Yu-su-fu,MUHADAISI Nu-er,ZHOU Wen-ting. Study on the biological mechanism of the action of Shenmai injection treatment of chronic heart failure by using integrative pharmacology[J]. The Chinese Journal of Clinical Pharmacology, 2021, 0(1): 75-77 | |
| Authors: | JIMILIHAN Si-ma-yi MAIMAITIMING Nu-er-mai-mai-ti AINIWAER Wu-mai-er NULIBIYA Mai-he-mu-ti MAIERDAN Yu-su-fu MUHADAISI Nu-er ZHOU Wen-ting |
| Affiliation: | (Department of Pharmacology,Xinjiang Medical University,Urumqi 830011,Xinjiang Autonomous Region,China;Department of Uyghur Medical,Xinjiang Medical University,Urumqi 830011,Xinjiang Autonomous Region,China) |
| Abstract: | From the perspective of traditional Chinese medicine Integrated pharmacology research platform(TCMIP V2.0),this paper explored the mechanism of Shenmai injection in the treatment of heart failure.With the analysis function of this platform,we constructed a multi-dimensional network of"traditional Chinese medicine-chemical components-core target-key pathway",and explored the potential molecular mechanism of Shenmai injection in treating heart failure from different perspectives.In TCMIP V2.0,the molecular mechanism of Shenmai injection in the treatment of heart failure was analyzed.The results showed that the chemical components of Shenmai injection mainly concentrated in ginsenosides and ophiopogon saponins.The common core targets of drugs and diseases include Na(+)/K(+)ATPase 1(ATP1 A1),tumor necrosis factor(TNF)and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma(PIK3 CG).It involves cAMP signaling pathway,estrogen signaling pathway,TNF signaling pathway and adrenergic signal transduction in cardiomyocytes. |
| Keywords: | integrated pharmacology Shenmai injection heart failure molecular mechanism |
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