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| 糖尿病周围神经病变中线粒体途径及相关通路凋亡机制研究进展 | |
| 引用本文： | 李欣,王雨,涂世伟,万星,陈龙菊. 糖尿病周围神经病变中线粒体途径及相关通路凋亡机制研究进展[J]. 中国中医药现代远程教育, 2021, 0(4): 200-204 |
| 作者姓名： | 李欣 王雨 涂世伟 万星 陈龙菊 |
| 作者单位： | 湖北民族大学医学部解剖教研室;湖北中医药大学基础医学院;湖北民族大学医学部机能教研室 |
| 基金项目： | 湖北省重点实验室第四批开放基金资助项目(No.OIR19007A)。 |
| 摘 要： | 糖尿病周围神经病变(Diabetic peripheral neuropathy,DPN)是糖尿病(Diabetes mellitus,DM)终末期并发症,为DM神经病变的主要形式,临床具有高病发率、高致残率特点,严重危害患者的生命健康.研究表明,在DPN外周神经系统中存在大量施万细胞及神经元凋亡,但其具体发病机制仍有... |
| 关 键 词： | 细胞凋亡 线粒体途径 信号通路 糖尿病 周围神经病变 消渴 痹证 |
Research Progress on the Role and Mechanism of Mitochondrial Apoptosis in Diabetic Peripheral Neuropathy |
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| LI Xin,WANG Yu,TU Shiwei,WAN Xing,CHEN Longju. Research Progress on the Role and Mechanism of Mitochondrial Apoptosis in Diabetic Peripheral Neuropathy[J]. Chinese Medicine Modern Distance Education of China, 2021, 0(4): 200-204 | |
| Authors: | LI Xin WANG Yu TU Shiwei WAN Xing CHEN Longju |
| Affiliation: | (Department of Anatomy,Health Science Center,Hubei Minzu University,Hubei Province,Enshi 445000,China;School of Basic Medical Sciences,Hubei University of Chinese Medicine,Hubei Province,Wuhan 430065,China;Department of Functional Medicine,Health Science Center,Hubei Minzu University,Hubei Province,Enshi 445000,China) |
| Abstract: | Diabetic peripheral neuropathy(DPN)is an end-stage complication of diabetes mellitus(DM),and is the main form of DM neuropathy.Clinically,it is characterized by high incidence rate and high disability rate,which seriously endangers the life and health of patients.Studies have shown that there are a large number of Schwann cells and neuronal apoptosis in the peripheral nervous system of DPN,but the specific pathogenesis remains to be expanded.As the power source and metabolic center,mitochondria plays a key role in the regulation of apoptosis,and the regulation of its pathways and related signaling pathways can prevent and treat DPN.This article reviews the relationship between mitochondrial apoptosis pathway and its related regulatory pathways and DPN,in order to provide some references for further discussion of the pathological mechanism of DPN. |
| Keywords: | apoptosis mitochondrial pathway signaling pathway diabetes peripheral neuropathy consumptive thirst arthromyodynia |
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