| 碱性成纤维细胞生长因子（bFGF）加速猪背部创伤修复的实验研究 |
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| 引用本文： | 付小兵,王亚平.碱性成纤维细胞生长因子（bFGF）加速猪背部创伤修复的实验研究[J].中华创伤杂志,1995,11(3):134-136. |
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| 作者姓名： | 付小兵 王亚平 |
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| 作者单位： | 解放军三０四医院创伤中心，军事医学科学院二所 |
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| 摘 要： | 实验采用猪背部创伤模型，观察重组的碱性成纤维细胞生长因子（ｂＦＧＦ）对创伤修复的作用。在无菌条件下用特制打孔器在猪背部切割皮肤，形成２．５ｃｍ２的园型创面。将１５０个创面分成５组，分别以ｂＦＧＦ（６０ｕ／ｃｍ２创面），ｂＦＧＦ（（６０ｕ／ｃｍ２创面）加ＳＤ－Ａｇ、ＳＤ－Ａｇ、生理盐水以及不治疗等方法处理，每间隔一天换药一次。实验结果表明，ｂＦＧＦ具有显著促进肉芽组织生长、加速创面再上皮化率以及增加创面愈合组织抗张力强度等作用。ＦＧＦ显著促修复效应的确切机制尚不完全清楚，可能包括直接与间接效应两方面。
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| 关 键 词： | 创伤 生长物质 肉芽组织 伤口愈合 细胞生长因子 |
Role of Fibroblast Growth Factor(bFGF) in Incised Wound Healing in Pigs |
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| FU Xiao bing,WANG Ya ping,CHANG Guo you,et al..Role of Fibroblast Growth Factor(bFGF) in Incised Wound Healing in Pigs[J].Chinese Journal of Traumatology,1995,11(3):134-136. |
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| Authors: | FU Xiao bing WANG Ya ping CHANG Guo you |
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| Institution: | FU Xiao bing,WANG Ya ping,CHANG Guo you,et al. Trauma Center of Postgraduate Medical College,304th Hospital,Beijing 100037 |
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| Abstract: | The role of basic fibroblast growth factor (bFGF) in incised wound healing was studied in 15 pigs.One hundred and fifty circle wounded areas on pigs' dorsum (1.8 cm in diameter) were divided into 5 groups and treated with five kinds of methods which were bFGF only (60u/cm 2),silver sulfadiazine cream containing bFGF(60u/cm 2),silver sulfadiazine cream only,saline only and normal control without any treatment.The results showed that the quantity of new granulation tissue in both bFGF treated wounds was more than that in other three groups.Also,the percentage of reepithelization and tissue breaking strength in bFGF treated wounds were greatly improved at day 7 ( P <0.05).We conclude that bFGF shows significantly promoting effects on wound healing.The mechanisms may include both direct and indirect effects.(Original article on page 134) |
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| Keywords: | Wounds and injuries Wound healing Growth substances Granulation tissue |
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