BCSG1 survivin在浸润性乳腺癌中的表达及预后相关性的研究

目的: 探讨BCSG1、survivin蛋白在浸润性乳腺癌中表达的意义及其相关性。 方法: 采用免疫组化SP法检测100例浸润性乳腺癌组织中BCSG1、survivin蛋白的表达情况,同时取10例正常乳腺组织作对照。 结果: BCSG1、survivin在浸润性乳腺癌中阳性表达分别为65%(65/100)、67%(67/100),二者在浸润性乳腺癌中的表达存在着明显的相关性(r=0.288,P<0.01),进一步发现共表达率达到50%,明显高于c-erbB-2的阳性率,BCSG1、survivin共表达和共表达阴性且c-erbB-2阴性的两组病例淋巴结转移情况分别为86.4%(19/22)和17.6%(3/17),有显著性差异(P<0.01)。 结论: 在c-erbB-2阴性表达乳腺癌病例中,BCSG1、survivin共阳性表达者淋巴结转移率明显高于BCSG1和survivin均呈阴性表达者,BCSG1、survivin的共表达可能是不好的预后因素。因此,同时检测BCSG1、survivin和c-erbB-2的表达对乳腺癌生物学行为的判定可能更有价值。

The Expression of BCSG1 and Survivin in Invasive Breast Cancer and Its Significance for Prognosis

Objective: To explore the significance of the expression of BCSG1 and Survivin and their correlation in invasive breast cancer. Methods: The expression of BCSG1 and Survivin were determined with the SP immunohistochemistry in 100 samples of invasive breast cancer and 10 samples of normal breast tissues. Results: The expression rates of BCSG1 and Survivin were 65% (65/100) and 67% (67/100) respectively, and were correlated with cerbB-2 expression rate and lymph node metastasis (P<0.05). The cerbB-2 expressio...