| 氟罗沙星注射液与抗感染中药注射液配伍的稳定性 |
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| 引用本文： | 祝永明,李士敏,吴筱丹,潘学仙,涂厉标.氟罗沙星注射液与抗感染中药注射液配伍的稳定性[J].中国临床药学杂志,2004,13(2):90-93. |
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| 作者姓名： | 祝永明 李士敏 吴筱丹 潘学仙 涂厉标 |
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| 作者单位： | 1. 浙江省嘉兴市第二医院药剂科,嘉兴,314000
2. 浙江大学药物制剂研究所,杭州,310006 |
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| 基金项目： | 浙江省药学会药剂专业委员会医院药学科研基金资助. |
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| 摘 要： | 目的：研究氟罗沙星注射液与3种抗感染中药注射液配伍的稳定性。方法：考察溶液配伍前后的外观色泽、微粒数、pH值等变化情况，并采用HPLC法考察配伍液中氟罗沙星的稳定性。结果：氟罗沙星注射液与穿琥宁粉针剂配伍后溶液出现白色浑浊，并有沉淀析出；与双黄连注射液配伍后溶液呈轻微浑浊；与鱼腥草注射液配伍后12h内溶液澄明，外观色泽、微粒数和pH值均无明显变化，配伍液中氟罗沙星经HPLC测定含量稳定。结论：氟罗沙星注射液不宜与穿琥宁粉针、双黄连注射液配伍，与鱼腥草注射液配伍其含量稳定。
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| 关 键 词： | 氟罗沙星注射液 抗感染中药注射液 药物配伍 稳定性 |
| 文章编号： | 1007-4406(2004)02-0090-04 |
Compatible stability of fleroxacin injection mixing with anti-infection traditional medicine injection |
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| Zhu Yongming ,Li Shimin ,Wu Xiaodan ,Pan Xuexian ,Tu Libiao.Compatible stability of fleroxacin injection mixing with anti-infection traditional medicine injection[J].Chinese Journal of Clinical Pharmacy,2004,13(2):90-93. |
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| Authors: | Zhu Yongming Li Shimin Wu Xiaodan Pan Xuexian Tu Libiao |
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| Institution: | Zhu Yongming 1,Li Shimin 2,Wu Xiaodan 2,Pan Xuexian 1,Tu Libiao 1 |
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| Abstract: | AIM:To study the compatible stability of fleroxacin injection mixing with anti-infection traditional medicine injection. METHODS: The change after matching in external appearance, particulate, pH were observed, the content of fleroxacin was determined in mixed solution by HPLC. RESULTS: White muddy appeared and then deposited after mixing fleroxacin injection with Chuanhuning for injection. Light muddy appeared after mixing fleroxacin injection with Shuanghuanglian injection. The mixed solution kept clear after mixing fleroxacin injection with Yuxingcao injection in 12 h. The external apperance, particulate and pH didn't change obviously. The content of fleroxacin didn't change in mixed solution by HPLC. CONCLUSION: Fleroxacin injection could not combine with Chuanhuning for injection or Shuanghuanglian injection. The content of fleroxacin is stable after mixing Yuxingcao injection. |
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| Keywords: | fleroxacin Yuxingcao injection Chuanhuning for injection Shuanghuanglian injection compatibility stability HPLC |
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