CD4+CD25+-regulatory T cells from mouse to man |
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| Authors: | Wing K Suri-Payer E Rudin A |
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| Affiliation: | 1. Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany;2. Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden;3. and |
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| Abstract: | ![]()
Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells. |
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