补肾益冲丸的毒理学实验研究

目的 研究补肾益冲丸的毒理作用，以确保临床用药的安全性。方法 （1）急性毒性试验：以最大给药体积的补肾益冲丸药液予小鼠1d内灌胃给药3次后，连续观察7d。（2）长期毒性试验：大鼠80只随机分为高、中、低三个剂量组和空白组，口服给药，连续12周，停药后7d进行血液学测定及病理检查。结果 急性毒性试验测得补肾益冲丸的最大耐受量为105．12g／kg（生药量），相当于成人临床每日口服剂量的95．56倍；长期毒性试验表明，三个剂量组血液学检查、肝肾功能测定、主要脏器系数等各项指标与空白组比较均无显著差异；主要脏器病理检查未见异常。结论 补肾益冲丸临床剂量口服安全，无蓄积毒性。

The Experimental Study of Toxic Mechanism of BuShenYiChong Pill

Obujective:To study toxicology of BuShenYiChong pill,guarantee the safety of durgs in clin- ic.Methods:Tests of acute oral toxicity:To give the mice BuShenYiChong pill with the dosage as a climax thrice a day and observe the moratality of mice in 7 days;Tests of long oral toxicity:Eighty rats was divided four equal groups of high,moderate,low dosage and blank control,with repeated grastric perfusion for 12 weeks,then stop garaging for 7 days,perform blood routine testes,blood chemical analysis,pathological anatomic examination.Results:The maximal dose is more than 105.12g/kg,95.56 times of the dosage used in clinic for an adult.Tests of long oral toxicity:three dosage groups,blood routine testes,blood chemical analysis,organ coefficient of tats,pathological anatomic examina- tion were not found obvious abnormality,there was no significant difference between the test groups and the control in all tested parameters.Conclusion:BuShenYiChong pill has no distinct toxicity in clinical applicatoin.