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The first potent and selective non-imidazole human histamine H4 receptor antagonists |
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| Authors: | Jablonowski Jill A Grice Cheryl A Chai Wenying Dvorak Curt A Venable Jennifer D Kwok Annette K Ly Kiev S Wei Jianmei Baker Sherry M Desai Pragnya J Jiang Wen Wilson Sandy J Thurmond Robin L Karlsson Lars Edwards James P Lovenberg Timothy W Carruthers Nicholas I |
| Affiliation: | Johnson & Johnson Pharmaceutical Research and Development, L.L.C, 3210 Merryfield Row, San Diego, California 92121, USA. |
| Abstract: | Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described. |
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