| 逐痹胶囊对大鼠佐剂性关节炎的影响 |
| |
| 引用本文： | 李惠,金亚宏,原桂东,王素芬. 逐痹胶囊对大鼠佐剂性关节炎的影响[J]. 中国中药杂志, 2005, 30(7): 551-554 |
| |
| 作者姓名： | 李惠 金亚宏 原桂东 王素芬 |
| |
| 作者单位： | 中国中医研究院,中药研究所,北京,100700 |
| |
| 摘 要： | 目的:观察逐痹胶囊对大鼠佐剂性关节炎(adjuvantarthritis,AA)的影响及作用机制。方法:用福氏完全佐剂(CFA)诱导大鼠AA模型,MTT法检测脾淋巴细胞增殖能力,免疫组织化学方法检测踝关节滑膜白细胞介素1(IL-1),白细胞介素6(IL-6)含量,并且测量原发及继发性关节肿胀程度。结果:生药52,26,13g·kg-1体重灌胃大鼠,逐痹胶囊显著抑制AA大鼠原发及继发踝关节炎性肿胀;降低脾淋巴细胞增殖能力及踝关节滑膜内IL1,IL-6含量。结论:逐痹胶囊对大鼠AA有一定抑制作用。
|
| 关 键 词： | 逐痹胶囊 佐剂性关节炎 IL-1 IL-6 |
| 文章编号： | 1001-5302(2005)07-0551-04 |
| 收稿时间： | 2004-10-18 |
The effects of Zhubi capsule on adjuvant arthritis in rats |
| |
| LI Hui;JIN Ya-hong;YUAN Gui-dong;WANG Su-fen. The effects of Zhubi capsule on adjuvant arthritis in rats[J]. China Journal of Chinese Materia Medica, 2005, 30(7): 551-554 |
| |
| Authors: | LI Hui JIN Ya-hong YUAN Gui-dong WANG Su-fen |
| |
| Affiliation: | Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China. huiwli@sina.com |
| |
| Abstract: | Objective: To explore the therapeutic effects and mechanisms of Zhubi capsule on adjuvant arthritis(AA) in rats. Method: The model of rat was induced by intradermal injection of CFA. The perimeter of ankle joint was measured at different time points. Con A-induced splencyte proliferation was examined by MTT assay and the expression of IL-1, IL-6 in synovium was determined by immunohistochemical method. Result: After the preventive administration of Zhubi capsule(5.2, 2.6, 1.3 g·kg·d-1,×25 d ), it was found that Zhubi capsule significantly inhibited the primary and secondary ankle joint swelling. The increased Con A-induced splencyte proliferation reaction and the activated IL-1,IL-6 expression of AA rat were suppressed by the treatment with Zhubi capsule. |
| |
| Keywords: | zhubi capule adjuvnt arthritis IL-1 IL-6 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
