| Livin在口腔鳞癌浸润前沿中的表达及临床意义 |
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| 引用本文： | 蒋蕾,李向新,白玲,张来健,张昶. Livin在口腔鳞癌浸润前沿中的表达及临床意义[J]. 南方医科大学学报, 2010, 30(6) |
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| 作者姓名： | 蒋蕾 李向新 白玲 张来健 张昶 |
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| 作者单位： | 连云港市第一人民医院口腔科,江苏,连云港,222000;连云港市第一人民医院病理科,江苏,连云港,222000 |
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| 摘 要： | 目的 检测凋亡抑制蛋白Livin在口腔鳞癌浸润前沿和非前沿中的表达,探讨其在口腔鳞癌发生发展过程中可能的意义.方法 对48例口腔鳞癌浸润前沿和非前沿部分分别病理分级,应用免疫组织化学Max-VisionTM快捷二步法检测Livin在口腔鳞癌浸润前沿及非前沿部分的表达情况,并进行统计学分析.结果 48例口腔鳞癌浸润前沿和非前沿病理分级情况有显著性差异(P<0.01);Livin在浸润前沿中的表达强度明显高于非前沿部分,差异有显著性(P<0.01),其表达情况与浸润前沿病理分级情况旱正相关(r=0-329,P=0.022).结论 口腔鳞痛浸润前沿中Livin蛋白的高表达提示在浸润前沿部分肿瘤的凋亡抑制现象更为显著,其表达情况与肿瘤的恶性程度和复发转移倾向有关.
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| 关 键 词： | 口腔肿瘤 鳞状细胞癌 浸润前沿 Livin |
Expression of livin at the invasive tumor front of oral squamous cell carcinoma |
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| JIANG Lei,LI xiang-xin,BAI Ling,ZHANG Lai-jian,ZHANG Chang. Expression of livin at the invasive tumor front of oral squamous cell carcinoma[J]. Journal of Southern Medical University, 2010, 30(6) |
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| Authors: | JIANG Lei LI xiang-xin BAI Ling ZHANG Lai-jian ZHANG Chang |
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| Affiliation: | JIANG Lei1,LI Xiang-xin1,BAI Ling2,ZHANG Lai-jian1,ZHANG Chang2 1Department of Stomatology,2Department of Pathology,Lianyungang First People's Hospital,Lianyungang 222000,China |
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| Abstract: | Objective To study the expression of livin at the invasive tumor front of oral squamous cell carcinoma.Methods Forty-eight samples of oral squamous cell carcinoma were graded according to invasive front gading(IFG).The expression of livin was evaluated at the ITF and other parts of the same tumor using immunohistochemistry.Results Significant difference in the pathological grades was found between the ITF and the other parts of oral squamous cell carcinoma(P<0.01).The expression of livin at the ITF was sign... |
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| Keywords: | Livin |
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