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| 二氢吡啶类钙通道拮抗剂抗心肌肥厚作用依赖于其对N-型钙通道的阻断能力 | |
| 引用本文： | 罗琼,禢婉玲,席芳,廖禹林,北风政史.二氢吡啶类钙通道拮抗剂抗心肌肥厚作用依赖于其对N-型钙通道的阻断能力[J].南方医科大学学报,2010,30(4). |
| 作者姓名： | 罗琼 禢婉玲 席芳 廖禹林 北风政史 |
| 作者单位： | 1. 南方医科大学基础医学院院病理生理学教研室,广东,广州,510515;南方医科大学公共卫生与热带医学学院,广东,广州,510515 2. 南方医科大学基础医学院院病理生理学教研室,广东,广州,510515;南方医科大学南方医院心血管内科,广东,广州,510515 3. 西安陆军学院边防干部训练大队影像教研室,新疆呼图壁 4. 南方医科大学基础医学院院病理生理学教研室,广东,广州,510515 5. 日本国立循环病中心心血管内科,日本,大阪 |
| 基金项目： | 广东省人才引进基金，南方医科大学人才引进启动基金 |
| 摘 要： | 目的 比较三种兼有不同N-型钙通道阻滞力的二氢吡啶类钙通道阻断剂(CCB)的抗心肌肥厚作用并分析其可能机制.方法 在C57 BL/6小鼠上缩窄主动脉弓(TAC)制作心肌肥厚模型,7 d后检测血浆儿茶酚胺水平以明确交感神经系统是否被激活.分别用长效CCB氨氯地平、贝尼地平和短效CCB硝苯啶治疗TAC小鼠7d后评价心肌肥厚程度.培养新生大鼠心肌细胞.检测上述三种CCB对苯肾上腺素(Phe)刺激的蛋白合成有无抑制作用.结果 TAC7d后.小鼠血浆肾上腺素、去甲肾上腺素和多巴胺浓度均显著上升.三种CCB的抗心肌肥厚作用的强弱与其对N-型钙通道的阻滞能力相一致.氨氯地平最明显.即使在持续缓释给药的情况下,硝苯啶对心肌肥厚无抑制作用.在培养的心肌细胞种,对Phe刺激的蛋白合成,三种CCB的抑制作用与在体实验结果一致.结论 二氢吡啶类CCB抗心肌肥厚的作用依赖于其对N-型钙通道阻滞力,其机制可能与抑制交感神经有关. |
| 关 键 词： | 钙通道阻断剂 氨氯地平 贝尼地平 硝苯地平 心肌肥厚 儿茶酚胺 |
Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel |
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| LUO Qiong,XUAN Wan-ling,XI Fang,LIAO Yu-lin,KITAKAZE Masafumi.Antihypertrophic effect of dihydropyridines calcium channel blockers is dependent on their potential of blocking N-type calcium channel[J].Journal of Southern Medical University,2010,30(4). | |
| Authors: | LUO Qiong XUAN Wan-ling XI Fang LIAO Yu-lin KITAKAZE Masafumi |
| Institution: | LUO Qiong1,2,XUAN Wan-ling1,3,XI Fang4,LIAO Yu-lin1,KITAKAZE Masafumi5 Department of Pathophysiology,School of Basic Medical Sciences1,School of Public Health and Tropical Medicine2,Department of Cardiology,Nanfang Hospital3,Southern Medical University,Guangzhou 510515,China,4Department of Iconography,Frontier Carder Training School,Hutubi,Xingjiang,5Cardiovascular Division of Internal Medicine,National Cardiovascular Center,5-7-1 Fujishirodai,Suita,Osaka 565-8565,Japan |
| Abstract: | Objective To compare the effects of amlodipine,benidipine and nifedipine on myocardial hypertrophy and evaluate the underlying mechanism.Methods Myocardial hypertrophy model was created by transverse aortic constriction (TAC) in C57 BL/6 mice,and plasma catecholamine concentrations were measured 7 days after surgery to confirm the sympathetic activation.The 3 drugs were administered in TAC mice for 7 days and cardiac hypertrophy was evaluated according to the heart-to-body weight ratio (HW/BW).Effects of th... |
| Keywords: | calcium channel blocker amolodipine benidipine nifedipine hypertrophy catecholamine |
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