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Misonidazole and radiotherapy in lung cancer: A randomized double-blind trial |
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| Authors: | M.J. Mäntylä E.M. Nordman P.J. Ruotsalainen T.T. Kylmämaa |
| Affiliation: | 1. Department of Radiotherapy, Middle Finland Central Hospital, SF-40620 Jyväskylä 62, Finland;2. Department of Radiotherapy, Turku University Central Hospital, Turku, Finland;3. Department of Clinical Research, Hoffmann-La Roche Ltd., Espoo, Finland |
| Abstract: | Forty-six patients with inoperable bronchial cancer have been treated by a fractionated course of radiotherapy with misonidazole or placebo. The main purpose of the administration of the drug to these patients was to determine tumor response and safe dosage in clinical radiotherapy. It seems possible to enhance the radiosensitivity of human squamous cell cancer by misonidazole. |
| Keywords: | Misonidazole Fractionation Hypoxic-cell radiosensitizer Bronchial cancer |
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