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| 吲哚美辛-PEG 6000滴丸的研究 | |
| 引用本文： | 陆彬,卢丹. 吲哚美辛-PEG 6000滴丸的研究[J]. 药学学报, 1992, 27(3): 227-230 |
| 作者姓名： | 陆彬 卢丹 |
| 作者单位： | 华西医科大学药学院，新疆石河子医学院药剂学教研室 成都 610041，进修生 |
| 摘 要： | 以聚乙二醇6000(简称PEG 6000)为载体制成吲哚美辛滴丸。测得滴丸的溶解度比原药吲哚美辛增大一倍多,剂量减半时,滴丸对大鼠胃的刺激性显著降低,且仍有抑制基础胃酸分泌的作用。 |
| 关 键 词： | 吲哚美辛 聚乙二醇6000 滴丸 |
| 收稿时间： | 1990-08-27 |
STUDY ON PILULES OF INDOMETHACIN-PEG 6000 |
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| B Lu,D Lu. STUDY ON PILULES OF INDOMETHACIN-PEG 6000[J]. Acta pharmaceutica Sinica, 1992, 27(3): 227-230 | |
| Authors: | B Lu D Lu |
| Affiliation: | School of Pharmacy, West China University of Medical Sciences, Chengdu. |
| Abstract: | Indomethacin (IDM)-PEG 6000 pilules were prepared using PEG6000as the carrier. The solubility of IDM in IDM-PEG 6000 pilules was about twiceas much as pure IDM. When the effective dose of IDM -PEG 6000 was only half that ofIDM tablet, the irritation of IDM-PEG 6000 pilule on rat stomach was reducedsignificantly but it still manifested the action of inhibiting the secretion of basal gastricacid |
| Keywords: | Indomethacin PEG 6000 Pilule |
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