动态对比增强灌注磁共振成像在颅脑肿瘤的应用

动态对比增强灌注磁共振(MR)成像能提供非侵袭、生理状态下的脑组织微循环血供图，通过计算正常脑组织及肿瘤组织的局部血容量，评估肿瘤组织的血供状态；并有助于评估胶质瘤病理学级别的高低，确定肿瘤穿刺活检的部位，以及对胶质瘤、单发脑转移瘤、淋巴瘤和其他脑肿瘤切除放疗后复发与放射性坏死的诊断和鉴别诊断等；但在颅内脑外肿瘤及伴有血脑屏障严重破坏的脑肿瘤诊断仍存在一定的不足。

Application of dynamic contrast-enhanced perfusion MR imaging in intracranial tumors

Dynamic contrasted-enhanced perfusion MR imaging can provide noninvasive and physical maps of cerebral microcirculation. The tumor vascularities are assessed by calculating cerebral blood volumes of the normal cerebral tissue and tumor tissue from imaging signal intensities. This technique is helpful to better evaluate the histopathological grade of gliomas, determine the biopsy site for tumors. And it is very useful for the preoperative diagnosis of gliomas, solitary metastases, cerebral lymphomas, as well as differentiating tumor recurrence after surgical resection and radiotherapy from radiation necrosis. But there are some limitations in evaluating extraaxial tumors and cerebral tumors with severe breakdown of blood-brain barrier.