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| 肠道菌群在肾脏疾病及治疗中的研究进展 | |
| 引用本文： | 包满辰,邹建洲,俞小芳. 肠道菌群在肾脏疾病及治疗中的研究进展[J]. 复旦学报(医学版), 2020, 47(6): 923-928. DOI: 10.3969/j.issn.1672-8467.2020.06.020 |
| 作者姓名： | 包满辰 邹建洲 俞小芳 |
| 作者单位： | 1 复旦大学附属中山医院肾内科 上海 200032;2 上海市肾病与透析研究所 上海 200032;3 上海市肾脏疾病与血液净化重点实验室 上海 200032;4 上海市肾脏疾病临床医学中心 上海 200032 |
| 基金项目： | 国家自然科学基金（81970667）；上海市青年拔尖人才项目（2018） |
| 摘 要： | 肾脏疾病会影响肠道菌群的结构和丰度，而肠道菌群的紊乱也会增加尿毒症毒素的产生，加速肾脏疾病的进程。本文阐述了肠道菌群的构成和作用，探讨了肠道菌群与慢性肾脏病（chronic kidney disease，CKD）、终末期肾病（end-stage renal disease，ESRD）、腹膜透析、血液透析和肾移植的关系，并列举了通过调节肠道菌群治疗肾脏疾病的各类方法，包括饮食疗法、益生菌、益生元、合生元、碳吸附剂和粪菌移植。 |
| 关 键 词： | 慢性肾脏病（CKD） 尿毒症 肠道菌群 |
| 收稿时间： | 2020-03-03 |
Research progress on roles of gut microbiota in kidney diseases and treatment |
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| BAO Man-chen,ZOU Jian-zhou,YU Xiao-fang. Research progress on roles of gut microbiota in kidney diseases and treatment[J]. Fudan University Journal of Medical Sciences, 2020, 47(6): 923-928. DOI: 10.3969/j.issn.1672-8467.2020.06.020 | |
| Authors: | BAO Man-chen ZOU Jian-zhou YU Xiao-fang |
| Affiliation: | 1.Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai 200032, China;2.Shanghai Institute of Kidney Disease and Dialysis, Shanghai 200032, China;3.Shanghai Key Laboratory of Kidney Disease and Blood Purification, Shanghai 200032, China;4.Shanghai Medical Center of Kidney, Shanghai 200032, China |
| Abstract: | Kidney diseases can affect the structure and abundance of gut microbiota,and the disorder of gut microbiota can also increase the production of uremia toxin,and accelerate the process of kidney diseases. In this review,we discussed the structure and role of gut microbiota,and the relationship between gut microbiota and chronic kidney disease (CKD),end-stage renal disease (ESRD),peritoneal dialysis,hemodialysis and renal transplantation.Gut microbiota can be a potential therapeutic target for kidney diseases. We summarized such targeted interventions including dietary,probiotic,prebiotic,symbiotic measures, oral carbon absorbent and fecal microbiota transplantation. |
| Keywords: | chronic kidney disease (CKD) uremia gut microbiota |
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