可手术的非小细胞肺癌患者TUBB3基因mRNA表达与预后相关性

 目的 探讨可手术的非小细胞肺癌人群中TUBB3基因mRNA表达水平和预后的相关性。方法 通过分支-DNA液相芯片技术定量检测92例非小细胞肺癌患者TUBB3基因mRNA表达,持续随访60个月,用Kaplan-Meier法绘制生存曲线,进行多因素分析。结果 在92例肺癌患者中,与不吸烟者相比,吸烟者的TUBB3基因mRNA表达水平明显更高(P=0.017)。随访结果显示:TUBB3 mRNA低表达的患者中位总生存期为48.7个月,长于高表达患者的生存期(35.8个月),差异有统计学意义(P=0.011,HR=1.56,95% CL:1.45~2.56)。TUBB3 mRNA低表达患者中位PFS为35.7个月,长于高表达患者中位PFS(23.5个月),差异有统计学意义(P=0.001,HR=1.33,95% CL:1.06~2.32)。结论 TUBB3 mRNA表达是可手术的非小细胞肺癌的预后因子。

Correlations between expressions of TUBB3 gene mRNA and prognosis in 92 patients of non-small cell lung cancer

Objective To evaluate the correlations between the expression of TUBB3 mRNA and the prognosis of NSCLC patients who can be treated surgically. Methods The expression of TUBB3 gene mRNA was detected with branch DNA liquid chips in 92 NSCLC patients who were followed up for 60 months. Results Low expressions of TUBB3 promised longer overall survival (48.7 vs 35.8 months, HR=1.56, 95% CL:1.45-2.56, P=0.017) in these patients. The median progression-free survival was longer in patients with low expressions of TUBB3 mRNA than in those with high expressions (35.7 months vs 23.5 months, P=0.001, HR=1.33,95% Cl:1.06-2.32). Conclusions TUBB3 mRNA expressions may be a factor that can help predict the prognosis of NSCLC patients.