重症病毒性肝炎补体系统激活与肝坏死的关系及意义的研究

Relationship Between Complement Activity and Liver Necrosis in Severe Viral Hepatitis

Serum C_(3d)/C_3,C_3,C_4 levels in severe viral hepatitis(SVH)and chronic activehepatitis(CAH),acute hepatitis,normal control showed significant statisticaldifferences.These suggested that there were large number of complement C_3breakdown products in SVH patients,whose complement systems were activatedintensively.In hepatic biopsy specimens of 20 cases of SVH and 8 cases of CAH,thepositive rates of complement C_3 precipitation in hepatical tissue were 85.0% and37.5% respectively and the positive rate of IgG in SVH was 75.0%.These suggestedthat marked complement activity existed in necrosis areas,degenerative or necrosis hepatic cells in SVH.Since complement activity would lead to inflammation and resulted in targetcells injury or death,it was demonstrated that complement system activity in SVHmight be an important cause of hepatonecrosis.