萘替芬酮康唑乳膏治疗足癣209例

目的：观察萘替芬酮康唑乳膏治疗足癣的安全性和疗效。方法：试验按随机双盲对照原则进行。足癣病人随机分成试验组(萘替芬酮康唑乳膏组)和对照组(萘替芬软膏组),均为每日早晚用药1次,于治疗1,2,3,4 wk及停药2 wk随访观察。结果：2组间性别、年龄、病期、病情严重程度积分等各项基础资料比较无显著差异(P＞0.05)。在治疗结束(4 wk)和停药2 wk时2组病人的临床疗效、真菌学疗效和综合疗效的差异无显著意义(P＞0.05)。治疗3 wk时真菌学清除率试验组96.1%,高于对照组的85.7%(P＜0.01),临床和综合疗效试验组均高于对照组(P＜0.05,P＜0.01)。试验组的不良反应发生率为2.4%,对照组为2.8%,2组比较差异无显著意义(P＞0.05)。结论：萘替芬酮康唑乳膏治疗足癣疗效好、安全性高。

Naftifine/ketoconazole cream in treatment of 209 patients with tinea pedis

AIM:To evaluate the safety and efficacy of naftifine/ketoconazole cream in treating tinea ped- is.METHODS:The clinical trial was carried out under the principle of random,double-blind and controlled. Patients with tinea pedis according to clinical signs and laboratory tests were randomly divided into trial group (treated with naftifine/ketoconazole cream)or control group(treated with naftifine cream).Creams were administered twice daily for 4 weeks.The clinical follow up was taken at 1,2,3,4 wk since the beginning of treatment and 2 wk after stopping the treatment.RESULTS:The basic conditions were matchable between the 2 groups(P＞0.05)before treatment.The clinical,mycological and integration effects of 2 groups had no statistically significant difference(P＞0.05)at the end of 4 wk treatment and 2 wk after stopping treatment.The mycological cure rate of trial group was 96.1%,higher than that of control group(85.7%,P＜0.01)at 3 wk since the initiation of treatment,the clinical and integration effects of trial group were also higher than those of the control group(P＜0.05,P＜0.01)at the same period since the treatment.The adverse reaction rates of trial and control group were 2.4% and 2.8%,respectively,showing no statistically significant difference(P＞0.05). CONCLUSION:Naftifine/ketoconazole cream is safe and efficient in treating tinea pedis.