血清胱抑素C、纤维蛋白原、C反应蛋白对早期糖尿病肾病的诊断价值

目的探讨血清胱抑素C（Cys-C）、血纤维蛋白原（Fg）、C反应蛋白（CRP）在早期糖尿病肾病（DN）中的临床诊断价值。方法收集糖尿病患者74例,根据尿白蛋白排泄率（UAER）将患者分为正常蛋白尿组（NA）27例、微量蛋白尿组（MA）31例和大量蛋白尿组（P）16例,观察3组患者及30例健康对照组Cys-C、Fg、CRP的变化。结果糖尿病患者血清Cys-C、Fg、CRP水平随病情加重逐渐升高,3组患者Cys-C、Fg、CRP比较差异均有统计学意义（P〈0.05）;正常蛋白尿组血Cys-C、Fg、CRP水平与对照组相比差异有统计学意义（P〈0.05）;微量蛋白尿组和大量蛋白尿组血Cys-C、Fg、CRP水平显著高于对照组和正常蛋白尿组,且大量蛋白尿组更为显著（P〈0.05）。结论 Cys-C、Fg、CRP水平可作为早期糖尿病肾病诊断的参考指标。

The diagnostic value of Cystatin C, Fibrinogen, C-reactive Protein in early diagnosis of diabetic nephropathy

Objective To investigate the clinical application value of cystatin C(Cys-C),fibrinoge-n(Fg) and C-reactive protein(CRP) levels in early diabetic nephropathy(DN) patients.Methods Seventy four patients were divided into 3 groups according to urinary albumin excretion rate(UAER),the normal albuminuria group(NA),the microalbuminuria group(MA) and the clinical proteinuria group(P),observed the levels of Cys-C,CRP and Fg in 3 groups and 30 healthy cases(control group).Results Cys-C,Fg and CRP were significantly higher in diabetic group,and the level increased gradually with illness progresses,there were significantly of Cys-C,Fg and CRP in NA,MA,P groups(P < 0.05);Cys-C,Fg and CRP were signicantly increased in MA and P groups compared with NA and control groups,especilly in P group(P < 0.05).Conclusion The levels of Cys-C,Fg,CRP can be used for reference indexes in early diabetic nephropathy.