siRNA技术在哮喘治疗中的应用 |
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引用本文: | 倪振华,王雄彪.siRNA技术在哮喘治疗中的应用[J].中国当代医药,2012,19(2):12-13. |
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作者姓名: | 倪振华 王雄彪 |
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作者单位: | 1. 上海市普陀区中心医院实验中心,上海200062;上海市中医药大学中西医结合肿瘤介入研究所,上海200062 2. 上海市普陀区中心医院呼吸科,上海,200062 |
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基金项目: | 上海市科委基础研究重点项目,上海市科委引领计划项目,上海市教委科研创新项目 |
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摘 要: | RNA干扰是由双链RNA引发的序列特异的基因沉默现象,其中长度为21~23nt的小RNA分子(small inter-fering RNA,siRNA)是引起RNA干扰现象的直接原因。利用siRNA使基因沉寂从而调节目的蛋白的表达,在疾病的基因治疗中有巨大的应用价值。哮喘是一种常见的多发病,在治疗上仍面临极大的挑战。利用siRNA技术治疗哮喘是当今最新的一种治疗手段,虽然应用才刚刚起步,但其革命性的治疗理念,无疑给哮喘患者带来了新的希望。
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关 键 词: | RNA干扰 siRNA 哮喘 治疗 |
siRNA as a therapy for asthma treatment |
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Authors: | NI Zhenhua WANG Xiongbiao |
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Institution: | 1.Lab Center of Putuo Central Hospital, Shanghai 200062, China; 2.Interventional Cancer Institute of Chinese Integrative Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China; 3.Department of Respiratory Medicine of Putuo Central Hospital, Shanghai 200062, China |
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Abstract: | RNA interference is the process of gene silencing by 21-23 nucleotides double-stranded small interfering RNA molecules. RNAi via siRNAs now demonstrates great value in gene therapy by interfering with the expression of a specific gene. Asthma as a chronic airway inflammatory disease faces great challenges in treatment. However the therapeutic advantages of siRNAs show great promise of applying siRNAs to alleviate asthma symptoms. |
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Keywords: | RNA interference siRNA Asthma Therapy |
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