桑仙降压颗粒对自发性高血压大鼠CD34和心肌血管抑素蛋白密度表达的干预

目的通过桑仙降压颗粒对自发性高血压大鼠（spontaneously hypertensive rats,SHR）CD34和AS蛋白光密度值的干预,探讨其对微血管数目及血管新生抑制因子的作用及机制。方法 SHR随机分为3组,蒸馏水空白对照组、吲哒帕胺西药对照组、桑仙降压颗粒组,以Wister大鼠为正常对照,4周及8周后观察SHR心肌AS蛋白光密度及CD34的表达。结果相较空白对照组,4周及8周后桑仙降压颗粒组CD34表达均明显增多且心肌AS蛋白光密度值明显降低。结论桑仙降压颗粒能有效减轻SHR大鼠微血管损害,其机制之一可能与降低AS蛋白密度表达有关。

The Intervention study of Sang Xian Jiang Ya Granule on epression of myocardial CD34 and endostatin(AS) protein optical density of spontaneously hypertensive rats

Objective To observe the effect of Sang Xian Jiang Ya Granule(SXJYG) on spontaneously hypertensive rats(SHR) myocardial CD34 and endostatin(AS) protein optical density values,and investigate the intervention of SXJYG on microvascular number and angiogenesis inhibiting factor.Methods SHR were randomly divided into 3 groups:those gavaged by distilled water as the control group,those gavaged by indapamide as the control group of Western Medicine,SXJYG group,compared with wistar as normal control group.After 4 and 8 weeks,the expression of myocardial AS protein and CD34 were observed.Results Compared with the blank control group,after 4 and 8 weeks SXJG group CD34 expression were significantly increased but myocardial AS optical density value were decreased.Conclusion SXJXG can reduce the SHR rat microvascular damage,and one of its mechanisms may be related to the decrease of AS protein expression in relation to density.