血清MBP、S100B的变化在新生儿窒息中的临床意义

目的探讨髓磷脂碱性蛋白（MBP）与S100B蛋白在新生儿窒息中的变化及其与预后的关系。方法 41例新生儿窒息患儿为观察组,同时选取同期收治的正常新生儿20例为对照组,检测两组急性期及恢复期的MBP、S100B蛋白水平。结果恢复期及急性期MBP与S100B水平与对照组相比,P〈0.05,P〈0.01。重度组MBP与S100B水平与轻度组相比,显著升高,P〈0.01。观察组患儿急性期、恢复期的MBP和S100B水平呈显著正相关（r=0.839,r=0.845,P〈0.05）;重度组、轻度组血清MBP与S100B水平呈显著正相关（r=0.818,r=0.832,P〈0.05）。结论窒息新生儿外周血MBP、S100B蛋白水平明显增高,对血MBP及S100B蛋白检测有助于新生儿窒息预后关系诊断。

Clinical study on the variations of serum MBP and S100B protein levels in asphyxia neonatorum

Objective To study the variations of serum MBP and S100B protein levels in asphyxia neonatorum and the re - lation between the variations of serum MBP and S100B protein levels and the prognosis of asphyxia neonatorum. Methods Forty-one cases of children of neonatal suffocation as the observation group, at the same time, the same period the newborn selection were normal in 20 cases as control group, the level of the acute phase and the two groups of recovery MBP, S100B protein were tested. Results The recovery and the acute phase MBP and S100B level compared with the control groep, P<0.05, P<0.01. The S100B and MBP level in the severe group compared with the mild level group, a significant rise, P<0.01. The observation group in the acute phase of recovery, the children MBP and S100B level were a sig - nificant positive correlation (r = 0.839, r = 0.845, P<0.05); The MBP and S100B serum level in severe group and mild group were a significant positive correlation (r = 0.818, r = 0.832, P<0.05). Conclusion The levels of serum MBP and S100B in asphyxiated newborns increase significantly. It might be valuable for the diagnosis of neonatal asphyxia following brain damage that the detection of levels of serum MBP and S100B.