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| 布洛芬传递体的制备及体外透皮研究 | |
| 引用本文： | 郭伟英,聂传平,曹洪昭. 布洛芬传递体的制备及体外透皮研究[J]. 中国医药工业杂志, 2010, 41(3) |
| 作者姓名： | 郭伟英 聂传平 曹洪昭 |
| 作者单位： | 辽宁医学院药学院,辽宁锦州,121001 |
| 摘 要： | 采用正交设计优化布洛芬传递体处方,并以水-甲醇(20:80,用0.1%三氟乙酸调至pH 2.0)为流动相,HPLC法测定布洛芬含量.比较了几种促渗剂(3%月桂氮革酮、吐温-20、尿素、1,2-丙二醇)对布洛芬传递体体外透大鼠皮肤的影响.结果表明,3%月桂氮革酮的促渗效果最好,稳态渗透速率为(85.98±6.54)μg·cm~(-2)·h~(-1). |
| 关 键 词： | 布洛芬 传递体 体外透皮 渗透促进剂 制备 |
Studies on Preparation of Ibuprofen Transfersomes and Transdermal Behavior in vitro |
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| GUO Weiying,NIE Chuanping,CAO Hongzhao. Studies on Preparation of Ibuprofen Transfersomes and Transdermal Behavior in vitro[J]. , 2010, 41(3) | |
| Authors: | GUO Weiying NIE Chuanping CAO Hongzhao |
| Abstract: | The formulation of ibuprofen transfersomes was optimized by orthogonal design. The drug content was determined by HPLC with water-methanol (20 : 80, adjusted to pH 2.0 with 0.1% trifluoroacetic acid) as the mobile phase. The effects of four penetration enhancers (3% azone, Tween-20, urea and 1,2-propylene glycol) on the transdermal delivery of ibuprofen through rat skin in vitro were compared. The results showed that 3 % azone had the highest enhancing effect with the steady-state flux rate of (85.98±6.54)μg·cm~(-2)·h~(-1) |
| Keywords: | ibuprofen transfersomes in vitro transdermal behavior penetration enhancer preparation |
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