| 布洛芬生产中缩酮工艺改进 |
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| 引用本文： | 姜卓文,臧恒昌,胡广利,张琦. 布洛芬生产中缩酮工艺改进[J]. 齐鲁药事, 2013, 32(3): 136-138 |
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| 作者姓名： | 姜卓文 臧恒昌 胡广利 张琦 |
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| 作者单位： | 姜卓文 (山东大学药学院,山东,济南,250012;巨化集团公司制药厂,浙江,衢州,324004)； 臧恒昌 (山东大学药学院,山东,济南,250012)；胡广利 (巨化集团公司制药厂,浙江,衢州,324004)；张琦 (巨化集团公司制药厂,浙江,衢州,324004)； |
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| 摘 要： | 目的改进布洛芬生产中的缩酮反应工艺。方法新工艺使用浓硫酸替代对甲苯磺酸为缩酮催化剂,使用季戊四醇替代新戊二醇反应底物,并且通过正交实验对工艺进行优化设计。结果工艺改进路线可行。结论该工艺路线有生产成本下降等优点。
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| 关 键 词： | 布洛芬 工艺改进 季戊四醇 |
Improvement of the ketal process in ibuprofen production |
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| JIANG Zhuo-wen,ZANG Heng-chang,HU Guang-li,ZHANG Qi. Improvement of the ketal process in ibuprofen production[J]. qilu pharmaceutical affairs, 2013, 32(3): 136-138 |
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| Authors: | JIANG Zhuo-wen ZANG Heng-chang HU Guang-li ZHANG Qi |
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| Affiliation: | 1.School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China;2.Juhua Group Corporation Pharmaceutical Factory,Quzhou 324004,China) |
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| Abstract: | Objective To improve the ketalization of ibuprofen production.Methods In new process,concentrated sulfuric acid was instead of p-toluenesulfonic acid as ketal catalyst,and pentaerythritol was used as reaction substrate alternative neopentylglycol,and also optimizing the design of the technology by orthogonal experiment.Results The process improvement route was feasible.Conclusion The process route can reduce production cost. |
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| Keywords: | Ibuprofen Process improvement Pentaerythritol |
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