| 附子中双酯型生物碱的提取条件考察 |
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| 引用本文： | 满玉清,董宁霞,周灵芝,龚千锋,卢立明,李艳江.附子中双酯型生物碱的提取条件考察[J].齐鲁药事,2013,32(3):134-135. |
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| 作者姓名： | 满玉清 董宁霞 周灵芝 龚千锋 卢立明 李艳江 |
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| 作者单位： | 满玉清 (滨州医学院附属医院,山东,滨州,256603)； 董宁霞 (滨州医学院附属医院,山东,滨州,256603)； 周灵芝 (滨州医学院附属医院,山东,滨州,256603)； 龚千锋 (江西中医学院,江西,南昌,330004)；卢立明 (滨州医学院附属医院,山东,滨州,256603)；李艳江 (滨州医学院附属医院,山东,滨州,256603)； |
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| 摘 要： | 目的优化附子中乌头碱等双酯型生物碱的提取条件。方法通过正交试验对提取方法进行优选。结果提取溶剂和冷浸时间对试验结果有显著影响,其他因素影响不显著,最佳提取条件为药材粉碎成细粉,加10倍量乙醚和1倍量氨试液,放置16 h后,超声10 min。结论该方法稳定可靠,提取率较高。
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| 关 键 词： | 附子 正交试验 双酯型生物碱 提取条件 |
Study on optimum conditions of extracting diester diterpenoid alkaloids from Radix Aconiti Lateralis Preparata |
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| MAN Yu-qing,DONG Ning-xia,ZHOU Ling-zhi,GONG Qian-feng,LU Li-ming,LI Yan-jiang.Study on optimum conditions of extracting diester diterpenoid alkaloids from Radix Aconiti Lateralis Preparata[J].qilu pharmaceutical affairs,2013,32(3):134-135. |
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| Authors: | MAN Yu-qing DONG Ning-xia ZHOU Ling-zhi GONG Qian-feng LU Li-ming LI Yan-jiang |
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| Institution: | 1(1.Affiliated Hospital of Binzhou Medical University,Binzhou 256603,China;2.Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China) |
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| Abstract: | Objective To optimize the extraction conditions of diester diterpenoid alkaloids(DDAs)such as mesaconitine from Radix Aconiti Lateralis Preparata.Methods To optimize the process of extraction by orthogonal experiment.Results The solvent and time of extraction had significant effects to the experimental result while others insignificant.The optimal process were:the medical material was crushed to fine powder,add 10 times of diethyl ether(V/V)and 1 time of ammonia test solution(V/V),16 h laying and then extracted 10 min by ultrasonic.Conclusion The optimum method was stabilize,and had high extraction rate. |
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| Keywords: | Radix Aconiti Lateralis Preparata Orthogonal experiment Diester diterpenoid alkaloids Extraction conditions |
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