非心源性缺血性卒中近期再发危险因素分析

目的 探讨首发非心源性缺血性卒中且二级预防药物依从性好的患者近期再发的相关危险因素。 

Risk Factors of Recent Stroke Recurrence in Non-cardiogenic Ischemic Stroke Patients

Objective To explore the related risk factors of recent stroke recurrence in non-cardiac ischemic
stroke patients with good compliance with secondary preventive medication.
Methods Patients with non-cardiac ischemic stroke who were admitted into our hospital from
January 2014 to April 2016 were included in the retrospective cohort study, and the recurrence
group and the control group were divided according to the follow-up period of 1 year. Multi-factors
regression analysis was used to analyze the related factors.
Results A total of 258 patients with ischemic stroke were enrolled, of all patients, 27 ones (10.5%)
had recurrent stroke. Multi-factors regression analysis showed that age [odds ratio (OR) 1.66, 95%
confidence interval (CI) 1.28-2.13, P <0.001], hypertension (OR 3.23, 95%CI 2.27-3.92, P <0.001),
diabetes (OR 2.23, 95%CI 2.11-3.01, P <0.001), coronary atherosclerotic heart disease (OR 1.36,
95%CI 1.17-2.09, P =0.043), chronic obstructive pulmonary disease (OR 1.42, 95%CI 1.11-2.09,
P =0.031), obstructive sleep apnea hypopnea syndrome (OR 2.86, 95%CI 2.22-3.56, P <0.001),
glycosylated hemoglobin (OR 2.67, 95%CI 2.21-3.31, P <0.001), C reactive protein (OR 1.32,
95%CI 1.36-1.66, P =0.046), homocysteine (OR 2.52, 95%CI 2.05-3.55, P <0.001) and activities of
daily living (OR 2.10, 95%CI 1.87-2.53, P <0.001) were related to the recurrence of ischemic stroke.
Conclusion Senior age, hypertension, diabetes, coronary atherosclerotic heart disease, chronic
obstructive pulmonary disease, obstructive sleep apnea hypopnea syndrome, decreased dailyliving ability, high glycosylated hemoglobin, high C reactive protein, high homocysteine, are the
independent risk factors for the recurrence of ischemic stroke.