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脂肪组织来源的干细胞的研究进展
引用本文:阎继红,齐念民. 脂肪组织来源的干细胞的研究进展[J]. 国际生物医学工程杂志, 2007, 30(3): 172-175
作者姓名:阎继红  齐念民
作者单位:201101,上海交通大学生物技术研究所
摘    要:
来自中胚层的脂肪组织与骨髓组织一样含有大量能自我更新和多向系分化潜能的细胞群称为脂肪干细胞。其取材方便,来源丰富,可在体外稳定增殖传代。并与骨髓间充质干细胞有相似的多向分化表面标志CD105、STRO-1以及CD166受体。研究发现它具有多向系分化潜能,除可以分化为问充质来源的脂肪、骨,软骨、脂肪以及骨骼肌、心肌等细胞,也可诱导分化为来源于外胚层的神经细胞以及具有功能性的血管内皮细胞,用以修复骨、软骨、心肌、骨骼肌、血管以及神经等组织。其具有造血支持作用以及可被逆转录病毒、腺病毒以及慢病毒较高的转染效率等优点,可以作为基因转移良好的靶细胞。因而,脂肪来源的干细胞其有望成为组织工程、细胞治疗以及基因转染良好的种子细胞。

关 键 词:脂肪干细胞 多向分化潜能 种子细胞
文章编号:1673-4181(2007)03-0172-04
修稿时间:2006-08-08

Study development of adipose tissue-derived stem cells
YAN Ji-hong,QI Nian-min. Study development of adipose tissue-derived stem cells[J]. International Journal of Biomedical Engineering, 2007, 30(3): 172-175
Authors:YAN Ji-hong  QI Nian-min
Affiliation:Institute of Biotechnology , Shanghai Jiao Tong University, Shanghai 201101, China
Abstract:
Adipose tissue originated from mesoderm, like bone marrow, contains a population of cells that has extensive self-renewal capacity and the ability to differentiate along multiple lineages (termed adipose tissue-derived stem cells, ADSCs). The cells possessing this activity can be obtained in large numbers from adipose tissue, and could stably proliferated and differentiated in vitro. The cell surface phenotype of ADSCs is quite similar to BMSCs, which have three common markers (CD105, STRO-1, and CD166). These are used to identify cells with multilineage differentiation potential and are consistently expressed on ADSCs and BMSCs. ADSCs can be differentiate not only into such mesenchymal lineages as adipogenesis, chondrogenesis, osteogenesis, myogenesis, but also into neurogenesis of origin ectoderm to restore functional capacity of damaged bone, cartilage, muscle, cardiovascular and nerve in vivo. In addition, ADSCs have high infected efficiency by adenoviral, oncoretroviral, and lentiviral vectors and have the ability to support hematopoiesis.Thus, ADSCs appears to represent a potential clinically useful source of cells for cellular therapy, tissue engineering and gene transfer applications.
Keywords:adipose tissue-derived stem cells    cell differentiation    seeded cell
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