支气管哮喘患者血清可溶性细胞间粘附分子-1和白介素-4水平测定及其临床意义

目的：了解和评价血清可溶性细胞间粘附分子（sICAM-1）和白介素-4（IL-4）在支气管哮喘发病过程中的作用。方法：采用酶联免疫吸附试验（ELISA）~JJ定43例支气管哮喘患者急性发作期血清sICAM-1、IL-4的水平并对其中38例恢复期血清sICAM-1、IL-4的水平进行检测，同时以30例正常人作为对照。结果：急性发作组血清sICAM-1、IL-4较缓解期及对照组明显升高；支气管哮喘急性重度发作组血清sICAM-1水平明显高于支气管哮喘急性轻、中度发作组。结论：sICAM-1可能参与了支气管哮喘的发病过程，可作为判断病情严重程度和治疗效果的临床指标。

Study on the Level of Soluble Intercellular Adhesion Molecule-1 and Interleukin-4 in the Serum from Patients with Bronchi Asthma and its Clinical Significance

Objective: To investigate and evaluate the effect of soluble intercellular adhesion molecule-1(sICAM- 1)and interleukin-4(IL-4) in pathogenesis of patients with bronchi asthma. Methods:Serum sICAM-1 was measured in 43 patients with asthmatic acute attack,and 30 healthy volunteers served as control group. After therapy 38 patients(remission period) had been detected concentrations of sICAM-1 and IL-4 again. sICAM-1 and IL-4 in serum were detected by ELISA. Results:The level of sICAM-1 and IL-4 greatly raised in asthmatic acute attack and remission period than control group. Conclusion: sICAM-1 may take part in the process of Bronchi asthma. The concentration of sICAM-1 in serum may be a useful parameter in judgment of the severity of Bronchi asthma and evaluation of therapeutic efficiency.